Protective Effects of Lycopene and Tomato Extract Against Doxorubicin-Induced Cardiotoxicity Cardioprotective effect of lycopene
Iranian Journal of Pharmaceutical Sciences,
Vol. 1 No. 2 (2005),
1 April 2005
,
Page 85-90
https://doi.org/10.22037/ijps.v1.39448
Abstract
The protective effect of tomato extract and lycopene on acute doxorubicin-induced myocardial toxicity was evaluated in mice. Doxorubicin toxicity, induced by a
single intraperitoneal injection (15 mg/kg), was revealed by elevated serum CPKMB and histopathological observations. Tomato extract (1.2 and 2.4 g/kg, i.p.) and
lycopene (1.7 and 3.5 mg/kg, i.p.), prevented the rise in serum CPKMB and ameliorated cardiac cell injury. These results suggest that tomato extract and
lycopene inhibit doxorubicin-induced cardiotoxicity and might serve as a combination chemotherapeutic agent with doxorubicin to limit its cardiotoxic effects.
- Doxorubicin
- Cardiotoxicity
- Tomato
- Lycopene
How to Cite
References
[2] Singal PK, Deally CM, Weinberg LE. Subcellular effects of adriamycin in the heart. J Mol Cell Cardiol 1987; 19: 817- 28.
[3] Doroshow JH. Anthracycline antibiotic stimulated superoxide, hydrogen peroxide and hydroxyl radical production by NADH dehydrogenase. Cancer Res 1983;
43: 4543-51.
[4] Griffin-Green EA, Zaleska MM, Erecinska M. Adriamycin induced lipid peroxidation in mitochondria and microsomes. Biochem Pharmacol 1988; 37: 3071-7.
[5] DerMarderosian A. The review of natural products. Facts and Comparisons. St. Louis: 2001, p. 379.
[6] DiMascio P, Kaiser S, Sreies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274 : 532-8.
[7] Ziegler RG, Vogt TM. Tomatoes, lycopene and risk of prostate cancer. Pharm Biology 2002; 40: 59-69.
[8] Lin CH, Chen BH. Determination of carotenoids in tomato juice by liquid chromatography. J Chromatogr A 2003; 1012: 103-9.
[9] Oliver IT. Improved method for determination of creatine kinase. J Lab Clin Med 1963; 62: 159-64.
[10]Kang YJ, Chen Y, Epstein PN. Suppression of doxorubicin cardiotoxicity by over expression of catalase in the heart of transgenic mice. J Biol Chem 1996; 271: 2610-6.
[11] Keizer HG, Pinedo HM, Schuurhuis GJ, Joenje H. Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol
Ther 1990; 47: 219-31.
[12] Agarwal S, Rao AV. Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. Lipids 1998; 33: 981-4.
[13] Kohlmeier L, Kark JD, Gomez-Garcia E, Martin BC, Steck SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R. Lycopene and myocardial infarction risk in the euramic study. Am J Epidemiol 1997; 146: 618-26.
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