Protective Effect of Rosmarinus officinalis L. Essential Oil against Free Radical-Induced Erythrocyte Lysis Cytoprotective effect of Rosmarinus officinalis
Iranian Journal of Pharmaceutical Sciences,
Vol. 1 No. 4 (2005),
1 Mehr 2005
,
Page 231-236
https://doi.org/10.22037/ijps.v1.39543
Abstract
The oxidative hemolysis of rat erythrocytes induced by 2,2’-azobis–(2-amidinopropane) (AAPH) and its inhibition by rosemary essential oil was studied. Different concentrations (0.178, 0.357, 0.534 and 0.712 μl/ml) of the essential oil showed no significant hemolysis compared to phosphate buffer solution. AAPH (25 mM and 50 mM) induced hemolysis in a time-dependent manner. Diff e r e n t concentrations of the essential oil inhibited hemolysis induced by 25 mM AAPH. However, in the presence of 50 mM of AAPH, only the two higher concentrations (0.534 and 0.712 μl/ml) of the essential oil inhibited hemolysis. Addition of essential
oil 2 or 3 h after incubation with AAPH had no significant effects on the time course of cell lysis. It is concluded that, in addition to its well-established antioxidant effects, rosemary essential oil displays cytoprotective properties.
- AAPH
- Hemolysis
- Rosmarinus officinalis
How to Cite
References
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