Effects of Quercetin and ACTH on Morphine-Induced Tolerance and Dependence in Mice Attenuation of morphine tolerance by quercetin
Iranian Journal of Pharmaceutical Sciences,
Vol. 2 No. 3 (2006),
1 July 2006
,
Page 137-142
https://doi.org/10.22037/ijps.v2.39736
Abstract
The goal of this study was to evaluate the effects of quercetin and ACTH injection on prevention of development of morphine tolerance and dependence in mice. In this study different groups of mice received morphine (40 mg/kg, i.p.) plus quercetin (5, 10, 25 mg/kg, ip), ACTH (1, 2.5, 5 IU/mice, i.p.), or combination of quercetin (5 mg/kg) and ACTH (1 IU/mice) once a day for four days. Tolerance was assessed by administration of morphine (9 mg/kg) and using hot plate test on the fifth day. It was found that pretreatment with quercetin or ACTH decreased the degree of tolerance. Co-administration of quercetin and ACTH before morphine did not decrease the tolerance, significantly. From these results it may be concluded that administration of quercetin or ACTH alone could prevent the development of tolerance to the analgesic effects of morphine. These effects may be related to as nitric oxide inhibitor (eNOI) behavior of quercetin and the ability of morphine and their receptors in the control of the secretion of CRH.
- ACTH
- Morphine
- Quercetin
- Tolerance
How to Cite
References
[2] Wise RA. Drug-activation of brain reward pathways. Drug Alcohol Depend 1998; 51: 13-22.
[3] Nestler EJ, Aghajanian GK. Molecular and cellular basis of addiction. Science 1997; 278: 58- 63.
[4] Calomme M, Pieters L, Vlietinck A, Vanden Berghe D. Inhibition of bacterial mutagenesis by Citrus flavonoids. Planta Med 1996; 62: 222-6.
[5] Ju-Ichi M. Chemical study of citrus plants in the search for cancer chemopreventive agents. Yakugaku Zasshi 2005; 125: 231-54.
[6] Timoshin AA, Dorkina EG, Paukova EO, Vanin AF. Quercetin and hesperidin decrease the formation of nitric oxide radicals in rat liver and heart under the conditions of hepatosis. Biofizika 2005; 50: 1145-9.
[7] Cho JY, Park SC, Kim TW, Kim KS, Song JC, Kim SK, Lee HM, Sung HJ, Park HJ, Song YB, Yoo ES, Lee CH, Rhee MH. Radical scavenging and anti-inflammatory activity of extracts from Opuntia humifusa Raf. J Pharm Pharmacol 2006; 58: 113-9.
[8] Haggag EG, Abou-Moustafa MA, Boucher W, Theoharides TC. The effect of a herbal waterextract on histamine release from mast cells and on allergic asthma. J Herb Pharmacother 2003; 3: 41-54.
[9] Ajay M, Achike FI, Mustafa AM, Mustafa MR. Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: A comparative study with ascorbic acid. Clin Exp Pharmacol Physiol 2006; 33: 345-50.
[10] Prem Kumar I, Rana SV, Samanta N, Goel HC. Enhancement of radiation-induced apoptosis by Podophyllum hexandrum. J Pharm Pharmacol 2003; 55: 1267-73.
[11] Rodgers EH, Grant MH. The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells. Chem Biol Interact 1998; 116: 213-28.
[12] Naidu PS, Singh A, Joshi D, Kulkarni SK. Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence. Addict Biol 2003; 8: 327-36.
[13] Hendrie CA. ACTH: a single pretreatment enhances the analgesic efficacy of and prevents the development of tolerance to morphine. Physiol Behav 1988; 42: 41-5.
[14] Jackson SJ, Venema RC. Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells. J Nutr 2006; 136:1178-84.
[15] Nestler EJ, Aghajanian GK. Molecular and cellular basis of addiction. Science 1997; 278: 58- 63.
[16] Liu JG, Anand KJ. Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence. Brain Res Rev 2000; 38: 1-19.
[17] Rang HP, Dale MM, Ritter JM. Pharmacology, drug dependence and drug abuse. Edinburgh: Churchill Livingstone 1999; pp. 470-82.
[18] Begon S, Pickering G, Eschalier A, Dubray C. Magnesium increases morphine analgesic effect indifferent experimental models of pain. Anesthesiology 2002; 96: 627-32.
[19] Elliott K, Kest B, Man A, Kao B, Inturrisi CE. Nmethyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development. Neuropsychopharmacology 1995; 13: 347-56.
[20] Zarauza R, Saez-Fernandez AN, Iribarren MJ, Carrascosa F, Adame M, Fidalgo I, Monedero P. A comparative study with oral nifedipine, intravenous nimodipine, and magnesium sulfate in postoperative analgesia. Anesth Analg 2000; 91: 938-43.
[21] Fallon JH, Loughlin SE. Substantia nigra. In: Paxinos G, (editor). The rat nervous system. Orlando: Academic Press, 1995; pp. 215-37.
[22] Mereu G, Costa E, Armstrong DM, and Vicini S. Glutamate receptor subtypes mediated excitatory synaptic currents of dopamine neurons in midbrain
slices. J Neurosci 1991; 11: 1359-66.
[23] Shen Z, Johnson SW. A slow excitatory postsynaptic current mediated by G proteincoupled metabotropic glutamate receptors in rat ventral tegmental dopamine neurons. Eur J Neurosci 1997; 9: 48-54.
[24] Santamarta MT, Ulibarri I, Pineda J. Inhibition of neuronal nitric oxide synthase attenuates the development of morphine tolerance in rats. Synapse 2005; 57: 38-46.
[25] Slamberova R, Rimanoczy A, Riley MA, Vathy I. Hypothalamo-pituitary-adernal axis-regulated stress response and negative feedback sensitivity is altered by prenatal morphine exposure in adult female rats. Neuroendocrinology 2004; 80: 192- 200.
[26] El Daly ES. Influence of acute and chronic morphine or stadol on the secretion of adrenocorticotrophin and its hypothalamic releasing hormone in the rat. Life Sciences 1996; 59:1881- 90.
- Abstract Viewed: 92 times
- IJPS_Volume 2_Issue 3_Pages 137-142 Downloaded: 37 times