Comparison of the Effect of Hydrophilicity on Biocompatibilityand Platelet Adhesion of Two Different Kinds of Biomaterials Effect of hydrophilicity on biocompatibility of biomaterialsRoswell
Iranian Journal of Pharmaceutical Sciences,
Vol. 4 No. 1 (2008),
15 January 2008
,
Page 37-44
https://doi.org/10.22037/ijps.v4.39813
Abstract
Determination of blood compatibility is an important problem in blood contactingdevices. In this study, two classes of materials including polyurethane (based onpolyethylene glycol and poly tetrametylene oxide) and polyvinyl alcohol samples,with different hydrophilicity properties were synthesized and their physico-chemicalproperties were compared. Water uptake ratio, FTIR spectroscopy, and contactangle measurement were conducted. In vitrobiocompatibility experiments wereundertaken using L-929 fibroblast cell lines which demonstrated desired cellviability for all samples after 7 days. The adhesion of platelets from human plasmawas studied by optical microscopy. Blood coagulation time were also determinedwhich revealed polyurethane based poly tetramethylene oxide has better interactionby blood elements among all samples.
Keywords:
- Biomaterial
- Hydrophilicity
- Platelet adhesion
- Polyurethane
- Polyvinylalcohol
How to Cite
Bonakdara, S. ., Orang, F. ., Rafienia, M. ., & Imani, R. . (2008). Comparison of the Effect of Hydrophilicity on Biocompatibilityand Platelet Adhesion of Two Different Kinds of Biomaterials: Effect of hydrophilicity on biocompatibility of biomaterialsRoswell. Iranian Journal of Pharmaceutical Sciences, 4(1), 37–44. https://doi.org/10.22037/ijps.v4.39813
References
[1]Simmons A, Hyvarinen J, Poole-Warren L. Theeffect of sterilization on a poly (dimethylsilox-ane)/poly (hexamethylene oxide) mixedmacrodiol-based polyurethane elastomer.Biomaterials2006; 27: 4484-97.
[2]Alperin C, Zandstra PW, Woodhouse KA.Polyurethane films seeded with embryonic stemcell-derived cardiomyocytes for use in cardiactissue engineering applications. Biomaterials2005; 26: 7377-86.
[3]Szycher M. Handbook of polyurethanes. NewYourk: CRC press. 1999; pp. 21-5.
[4]Klement P, Du YJ, Berry LR, Tressel P, ChanAKC. Chronic performance of polyurethanecatheters covalently coated with ATH complex:Arabbit jugular vein model. Biomaterials2006;27: 5107-17.
[5]Bernacca GM, O'Connor B, Williams DF, Wheatley DJ. Hydrodynamic function of polyurethane prosthetic heart valves: Influencesof Young's modulus and leaflet thickness.Biomaterials2002; 23: 45-50.
[6]Orang F, Plummer CJG, Kausch HH. Effect ofprocessing conditions and in vitro ageing on the Table physical properties of Biomer®. Biomaterials1996; 17: 485-90.
[7]Orang F, Zenhausern F, Emch R, Descouts P.Characterization of a biomedical polyurethanefor cardiovascular applications by AFM. 7thInternational Conference on Surface and ColloidScience. Compiegne, France. 1991; 7-13.
[8]Karbasi S, Mirzadeh H, Orang F, Urban JPG. Acomparison between cell viability ofchondrocytes on a biodegradable polyesterurethane scaffold and alginate beads in differentoxygen tension and pH. Iranian Polymer J2005;14: 823-30.
[9]Rafienia M, Orang F, Emami SH. Preparation andcharacterization of polyurethane microspherescontaining theophylline. J Bioactive CompatiblePolymers2006; 21: 341-9.
[10]Oh SH, Kang SG, Kim ES, Cho SH, Lee JH.Fabrication and characterization of hydrophilicpoly(lactic-coglycolic acid)/poly (vinyl alcohol)blend cell scaffolds by melt-molding particulate-leaching method. Biomaterials2003; 24: 4011-21.
[11]Hassan CM, Peppas NA. Structure and applicationof PVAhydrogels produced by conventionalcrosslinking or by freezing/thawing methods.Adv Polym Sci 2000; 153: 38-62.
[12]Llanos GR, Sefton MV. Heparin-poly(ethyleneglycol)-poly(vinyl alcohol) hydrogel: Preparationand assessment of thrombogenicity. Biomaterials1992; 13: 421-4.[13]Corkhill P, Trevett A, Tighe B. The potential ofhydrogels as synthetic articular cartilage. Proc InstMech Engrs1990; 204: 147-55.
[14]Peppas NA, Keys KB, Torres-Lugo M, LowmanAM. Poly (ethylene glycol)-containing hydrogelsin drug delivery. J Control Release1999; 62: 81-7.
[15]Vijayasekaran S, Fitton JH, Hicks CR, Chirila TV,Crawford GJ, Constable IJ. Cell viability andinflammatory response in hydrogel spongesimplanted in the rabbit cornea. Biomaterials1998;19: 2255-67.
[16]Young CD, Wu JR, Tsou TL. High-strength, ultra-thin and fiber-reinforced PHEMAartificial skin.Biomaterials1998; 19: 1745-52.
[17]Li JK, Wang N, Wu XS. Poly (vinyl alcohol)nanoparticles prepared by freezing-thawingprocess for protein/ peptide drug delivery. JControl Release1998; 56: 117-26.
[18]DiTizio V, Ferguson GW, Mittelman MW, KhouryAE, Bruce AW, DiCosmo F. Aliposomal hydrogelfor the prevention of bacterial adhesion tocatheters. Biomaterials1998; 19: 1877-84.
[19]Ditmer A, Hutmacher W. Scaffold tissueengineering, bone and cartilage. Biomaterials2000; 21: 2529-93.
[20]Tortora M, Cavalieri F, Chiessi E, Paradossi G.Michael-type addition reactions for the in situformation of poly (vinyl alcohol)-based hydrogels.Biomacromolecules2007; 8: 209-14.
[21]Maruoka S, Matsuura T, Kawasaki K, OkamotoM, Yoshiaki H, Kodama M, Sugiyama M, AnakaM. Biocompatibility of polyvinylalcohol gel as avitreous substitute.Curr Eye Res 2006; 31: 599-606.
[22]Ratner BD, Hoffman AS, Schoen FJ, LemonsJE. Biomaterials science. New York: AcademicPress, 2004; p. 197.
[23]Vijayanand K, Pattanayak DK, Rama Mohan TR,Banerjee R. Interpreting blood-biomaterialinteractions from surface free energy and work ofadhesion. Trends Biomater Artif Organs2005; 18:1873-81.
[24]Nivasu VM, Reddy TT, Tammishetti S. In situpolymerizable polyethyleneglycol containingpolyesterpolyol acrylates for tissue sealantapplications. Biomaterials2004; 25: 3283-91.43
[2]Alperin C, Zandstra PW, Woodhouse KA.Polyurethane films seeded with embryonic stemcell-derived cardiomyocytes for use in cardiactissue engineering applications. Biomaterials2005; 26: 7377-86.
[3]Szycher M. Handbook of polyurethanes. NewYourk: CRC press. 1999; pp. 21-5.
[4]Klement P, Du YJ, Berry LR, Tressel P, ChanAKC. Chronic performance of polyurethanecatheters covalently coated with ATH complex:Arabbit jugular vein model. Biomaterials2006;27: 5107-17.
[5]Bernacca GM, O'Connor B, Williams DF, Wheatley DJ. Hydrodynamic function of polyurethane prosthetic heart valves: Influencesof Young's modulus and leaflet thickness.Biomaterials2002; 23: 45-50.
[6]Orang F, Plummer CJG, Kausch HH. Effect ofprocessing conditions and in vitro ageing on the Table physical properties of Biomer®. Biomaterials1996; 17: 485-90.
[7]Orang F, Zenhausern F, Emch R, Descouts P.Characterization of a biomedical polyurethanefor cardiovascular applications by AFM. 7thInternational Conference on Surface and ColloidScience. Compiegne, France. 1991; 7-13.
[8]Karbasi S, Mirzadeh H, Orang F, Urban JPG. Acomparison between cell viability ofchondrocytes on a biodegradable polyesterurethane scaffold and alginate beads in differentoxygen tension and pH. Iranian Polymer J2005;14: 823-30.
[9]Rafienia M, Orang F, Emami SH. Preparation andcharacterization of polyurethane microspherescontaining theophylline. J Bioactive CompatiblePolymers2006; 21: 341-9.
[10]Oh SH, Kang SG, Kim ES, Cho SH, Lee JH.Fabrication and characterization of hydrophilicpoly(lactic-coglycolic acid)/poly (vinyl alcohol)blend cell scaffolds by melt-molding particulate-leaching method. Biomaterials2003; 24: 4011-21.
[11]Hassan CM, Peppas NA. Structure and applicationof PVAhydrogels produced by conventionalcrosslinking or by freezing/thawing methods.Adv Polym Sci 2000; 153: 38-62.
[12]Llanos GR, Sefton MV. Heparin-poly(ethyleneglycol)-poly(vinyl alcohol) hydrogel: Preparationand assessment of thrombogenicity. Biomaterials1992; 13: 421-4.[13]Corkhill P, Trevett A, Tighe B. The potential ofhydrogels as synthetic articular cartilage. Proc InstMech Engrs1990; 204: 147-55.
[14]Peppas NA, Keys KB, Torres-Lugo M, LowmanAM. Poly (ethylene glycol)-containing hydrogelsin drug delivery. J Control Release1999; 62: 81-7.
[15]Vijayasekaran S, Fitton JH, Hicks CR, Chirila TV,Crawford GJ, Constable IJ. Cell viability andinflammatory response in hydrogel spongesimplanted in the rabbit cornea. Biomaterials1998;19: 2255-67.
[16]Young CD, Wu JR, Tsou TL. High-strength, ultra-thin and fiber-reinforced PHEMAartificial skin.Biomaterials1998; 19: 1745-52.
[17]Li JK, Wang N, Wu XS. Poly (vinyl alcohol)nanoparticles prepared by freezing-thawingprocess for protein/ peptide drug delivery. JControl Release1998; 56: 117-26.
[18]DiTizio V, Ferguson GW, Mittelman MW, KhouryAE, Bruce AW, DiCosmo F. Aliposomal hydrogelfor the prevention of bacterial adhesion tocatheters. Biomaterials1998; 19: 1877-84.
[19]Ditmer A, Hutmacher W. Scaffold tissueengineering, bone and cartilage. Biomaterials2000; 21: 2529-93.
[20]Tortora M, Cavalieri F, Chiessi E, Paradossi G.Michael-type addition reactions for the in situformation of poly (vinyl alcohol)-based hydrogels.Biomacromolecules2007; 8: 209-14.
[21]Maruoka S, Matsuura T, Kawasaki K, OkamotoM, Yoshiaki H, Kodama M, Sugiyama M, AnakaM. Biocompatibility of polyvinylalcohol gel as avitreous substitute.Curr Eye Res 2006; 31: 599-606.
[22]Ratner BD, Hoffman AS, Schoen FJ, LemonsJE. Biomaterials science. New York: AcademicPress, 2004; p. 197.
[23]Vijayanand K, Pattanayak DK, Rama Mohan TR,Banerjee R. Interpreting blood-biomaterialinteractions from surface free energy and work ofadhesion. Trends Biomater Artif Organs2005; 18:1873-81.
[24]Nivasu VM, Reddy TT, Tammishetti S. In situpolymerizable polyethyleneglycol containingpolyesterpolyol acrylates for tissue sealantapplications. Biomaterials2004; 25: 3283-91.43
- Abstract Viewed: 315 times
- IJPS_Volume 4_Issue 1_Pages 37-44 Downloaded: 260 times