irMass TransferDuring the Pre-Usage Dehydration of PolyvinylAlcohol Hydrogel Wound Dressings Mass transfer during pre-usage dehydration of PVPhydrogels
Iranian Journal of Pharmaceutical Sciences,
Vol. 4 No. 1 (2008),
15 January 2008
,
Page 51-56
https://doi.org/10.22037/ijps.v4.39815
Abstract
Nowadays, hydrogels are widely used as wound dressings in biomedicalapplications. Similar to other types of the moist (wet) wound dressings, it isnecessary to have sufficient information about their dehydration kinetics during thepre-usage period (e.g. storage duration) and also the wound healing process. In thiswork, hydrogel wound dressings based on polyvinyl alcohol were prepared bycyclic freezing-thawing method and their dehydration process investigated byexperimental and mathematical methods. The dehydration tests were performed atatmospheric pressure at 37 °C, using hydrogels containing initial water content of70, 80 and 90 wt% and thickness of 1, 3 and 4 mm. The dehydration kinetics of eachhydrogel was determined by plotting the relative water loss (ratio of water loss toinitial water content) versus time. The obtained results showed that the dehydrationrate has inverse dependency to the thickness of wound dressing. On the other hand,the initial water content of the wound dressing has not significant effect on itsdehydration rate. To compare the obtained results with theoretical data, themathematical modeling on the basis of diffusion mechanism was developed topredict the dehydration process of the wound dressings. The results obtained fromthe mathematical modeling were in agreement with the experimental results showingthat the main phenomenon governing the dehydration of the wound dressings is thediffusion.
- Dehydration
- Hydrogel
- Mass transfer
- Polyvinyl alcohol
- Wound dressing
How to Cite
References
[2] Kokabi M, Sirousazar M, Hassan ZM. PVA-claynanocomposite hydrogels for wound dressing.Eur Polym J 2007; 43: 773-81.
[3]Purna SK, Babu M. Collagen based dressings-areview.Burns2000; 26: 54-62.
[4]Kannon GA, Garrett AB. Moist wound healingwith occlusive dressings, a clinical review.Dermatol Surg1995; 21: 583-90.
[5]Higa OZ, Rogero SO, Machado LDB, MathorMB, Lugao AB. Biocompatibility study for PVPwound dressing obtained in diferent conditions.Radiat Phys Chem1999; 55: 705-7.
[6]Razzak MT, Darwis D, Sukirno Z. Irradiation ofpoly vinyl alcohol and poly vinyl pyrrolidonebelended hydrogel for wound dressing. RadiatPhys Chem2001; 62: 107-13.
[7]Yoshii F, Zhanshan Y, Isobe K, Shiozaki K,Makunchi K. Electron beam crosslinked PEOand PEO/PVAhydrogels for wound dressing.Radiat Phys Chem 1999; 55: 133-8.
[8]Yoshii F, Makuuchi K, Darwis D, Iriawan T,Razzak MT, Rosiak JM. Heat resistance polyvinyl alcohol hydrogel. Radiat Phys Chem1995;46: 169-74.
[9]Varshney L. Role of natural polysaccharides inradiation formation of PVA-hydrogel wounddressing. Nucl Instrum MethB 2007; 255: 343-9.
[10]Peppas NA. Development of crosslinked PVAbiomembranes. Polym Prepr1977; 1: 794-7.
[11]Peppas NA. Turbidimetric studies of aqueouspoly vinyl alcohol solutions. Makromol Chem1975; 176: 3433-40.
[12]Staufer SR, Peppas NA. Poly vinyl alcoholhydrogels prepared by freezing-thawing cyclicprocessing. Polymer1992; 33: 3932-6.
[13]Hernandez R, Lopez D, Mijangos C, Guenet JM.Areappraisal of the "Thermoreversible" gelationof aqueous poly vinyl alcohol solutions throughfreezing-thawing cycles. Polymer2002; 43: 5661-3.55
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