The Analgesic Effect of Salvia reuterana The Analgesic Effect of Salvia reuterana
Iranian Journal of Pharmaceutical Sciences,
Vol. 17 No. 3 (2021),
1 July 2021
,
Page 63-70
https://doi.org/10.22037/ijps.v17.40274
Abstract
Salvia reuterana, commonly known as Maryam Goli Esfahani, is a member of the Labiateae family. In Iranian folk medicine, aerial parts of S. reuterana have been used as sedative and anxiety. Evaluation of various extracts of the plant for their analgesic activity revealed that treatment of mice with n-hexane extract (500 mg/kg, i.p.) significantly increased the latency time as compared to the control group. Fractionation of the hexane extract of S. reuterana led to the isolation of sclareol as the main compound (0.19% w/w). Column chromatography was used to isolation of compounds from S. reuterana and a spectroscopic method including NMR was used to identification of the isolated compound. Evaluation of the analgesic effect of sclareol using a hot plate, tail-flick, and formalin tests in mice confirmed the potent analgesic effect of sclareol as an effective compound of S. reuterana. These results showed that the n-hexane extract of aerial parts of S. reuterana and its main constituent sclareol showed significant analgesic activity in different rodent nociceptive behavioral tests.
Keywords:
- Analgesic Activity
- Formalin Test
- Hot Plate Test
- Salvia reuterana
- Sclareol
- Tail-Flick Test
How to Cite
Monsef Esfahani, H., Amirshahrokhi, K., Mashmool, A., Moridi Farimani, M., Dehpour, A., & Miran, M. (2021). The Analgesic Effect of Salvia reuterana: The Analgesic Effect of Salvia reuterana. Iranian Journal of Pharmaceutical Sciences, 17(3), 63–70. https://doi.org/10.22037/ijps.v17.40274
References
[1] Wu YB, Ni ZY, Shi QW, Dong M, Kiyota H, Gu YC, Cong B. Constituents from Salvia species and their biological activities. Chem. Rev. (2012) 112(11): 5967-6026.
[2] Imanshahidi M, Hosseinzadeh, H. The pharmacological effects of Salvia species on the central nervous system. Phytother Res. (2006) 20(6): 427-37.
[3] Moridi Farimani M, Miran M. Labdane diterpenoids from Salvia reuterana. Phytochemistry. (2014) 108: 264-269.
[4] Rechinger KH. Flora Iranica; Akademische druck und verlagsanstalt. Graz, Austria. (1987) 150, 403-476.
[5] Moridi Farimani M, Miran M, Nejad Ebrahimi S. New diterpenoids from the aerial parts of Salvia reuterana. Iran. J. Pharm. Res. (2019) 18(1): 406-411.
[6] Esmaeili A, Rustaiyan AH, Nadimi M, Larijani K, Nadjafi F, Tabrizi L, Chalabian F, Amiri H. Chemical composition and antibacterial activity of essential oils from leaves, stems and flowers of Salvia reuterana Boiss. grown in Iran. Nat. Prod. Res. (2008) 22(6): 516-520.
[7] Rabbani M, Sajjadi S.E, Jafarian A, Vaseghi G. Anxiolytic effects of Salvia reuterana Boiss. on the elevated plus-maze model of anxiety in mice. J. Ethnopharmacol. (2005) 101: 100-103.
[8] Koval’skaya S, Kozlov N, Kulcitki V, Aricu A, Ungur N. Transformation of sclareol under ritter reaction conditions. Russ. J. Org. (2013) 49.
[9] Tjølsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: An evaluation of the method. Pain. (1992) 51(1): 5-17.
[10] Akbar A, Tariq M, Nisa M. Pharmacological studies on Salvia haematodes Wall. Acta Trop. (1985) 42 (4): 371–374.
[11] Ustun O, Sezik E. Analgesic Activity of Salvia wiedemannii Boiss. Used in Turkish folk medicine. Rec. Nat. Prod. (2011) 5: 328-331.
[12] Amabeoku GJ, Eagles P, Scott G, Mayeng I, Springfield E. Analgesic and antipyretic effects of Dodonaea angustifolia and Salvia africana-lutea. J. Ethnopharmacol. (2001) 75(2): 117-124.
[13] Meyre-Silva C, Yunes RA, Schlemper V, Campos-Buzzi F, Cechinel-Filho V. Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae). Farmaco. (2005) 60(4): 321-326.
[14] Sun N, Qiu Y, Zhu Y, Liu J, Zhang H, Zhang Q, Yao G. Rhodomicranosides A−I, analgesic diterpene glucosides with diverse carbon skeletons from Rhododendron micranthum. Phytochemistry. (2019) 158: 1-12.
[15] Sun N, Feng Y, Zhang Q, Liu J, Zhou H, Zhang H, Yao G. Analgesic diterpenoids with diverse carbon skeletons from the leaves of Rhododendron auriculatum. Phytochemistry. (2019) 168: 112113.
[16] Chatter R, Kladi M, Tarhouni S, Maatoug R, Kharrat R, Vagias C, Roussis V. Neorogioltriol: A brominated diterpene with analgesic activity from Laurencia glandulifera. Phytochem. Lett. (2009) 2(1): 25-28.
[17] Hernandez-Perez M, Rabanal RM, De La Torre M C, Rodriguez B. Analgesic, anti-inflammatory, antipyretic and haematological effects of aethiopinone, an o-naphthoquinone diterpenoid from Salvia aethiopis roots and two hemisynthetic derivatives. Planta. Med. (1995) 61(6): 505-509.
[18] Wu PC, Chuo WH, Lin SC, Lehman CW, Lien CZ, Wu CS, Lin CC. Sclareol attenuates the development of atopic dermatitis induced by 2,4-dinitrochlorobenzene in mice. Immunopharmacol. Immunotoxicol. (2019) 41(1): 109-116.
[19] Noori S, Hassan ZM, Mohammadi M, Habibi Z, Sohrabi N, Bayanolhagh S. Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo. Cell Immunol. (2010) 263(2): 148-153.
[20] Mahaira LG, Tsimplouli C, Sakellaridis N, Alevizopoulos K, Demetzos C, Han Z, Dimas K. The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action. Eur. J. Pharmacol. (2011) 666(1): 173-182.
[21] Borges GSM, Silva JdO, Fernandes RS, de Souza ÂM, Cassali GD, Yoshida MI, Ferreira LAM. sclareol is a potent enhancer of doxorubicin: Evaluation of the free combination and co-loaded nanostructured lipid carriers against breast cancer. Life. Sci. (2019) 232: 116678.
[22] Dimas K, Kokkinopoulos D, Demetzos C, Vaos B, Marselos M, Malamas M, Tzavaras T. The effect of sclareol on growth and cell cycle progression of human leukemic cell lines. Leuk. Res. (1999) 23(3): 217-234.
[23] Campos DR, Celotto AC, Albuquerque AAS, Ferreira LG, Monteiro A, Coelho EB, Evora PRB. The diterpene sclareol vascular effect in normotensive and hypertensive rats. Arq. Bras Cardiol. (2017) 109(2): 117-123.
[24] Park JE, Lee KE, Jung E, Kang S, Kim YJ. Sclareol isolated from Salvia officinalis improves facial wrinkles via an antiphotoaging mechanism. J. Cosmet. Dermatol. (2016) 15(4): 475-483.
[25] Crusco A, Whiteland H, Baptista R, Forde-Thomas JE, Beckmann M, Mur LAJ, Hoffmann KF. Antischistosomal properties of sclareol and its heck-coupled derivatives: Design, synthesis, biological evaluation, and untargeted metabolomics. ACS Infect. Dis. (2019) 5(7): 1188-1199.
[26] Tsai SW, Hsieh MC, Li S, Lin SC, Wang SP, Lehman CW, Lin CC. Therapeutic potential of sclareol in experimental models of rheumatoid arthritis. Int. J. Mol. Sci. (2018) 19 (5): 1351.
[2] Imanshahidi M, Hosseinzadeh, H. The pharmacological effects of Salvia species on the central nervous system. Phytother Res. (2006) 20(6): 427-37.
[3] Moridi Farimani M, Miran M. Labdane diterpenoids from Salvia reuterana. Phytochemistry. (2014) 108: 264-269.
[4] Rechinger KH. Flora Iranica; Akademische druck und verlagsanstalt. Graz, Austria. (1987) 150, 403-476.
[5] Moridi Farimani M, Miran M, Nejad Ebrahimi S. New diterpenoids from the aerial parts of Salvia reuterana. Iran. J. Pharm. Res. (2019) 18(1): 406-411.
[6] Esmaeili A, Rustaiyan AH, Nadimi M, Larijani K, Nadjafi F, Tabrizi L, Chalabian F, Amiri H. Chemical composition and antibacterial activity of essential oils from leaves, stems and flowers of Salvia reuterana Boiss. grown in Iran. Nat. Prod. Res. (2008) 22(6): 516-520.
[7] Rabbani M, Sajjadi S.E, Jafarian A, Vaseghi G. Anxiolytic effects of Salvia reuterana Boiss. on the elevated plus-maze model of anxiety in mice. J. Ethnopharmacol. (2005) 101: 100-103.
[8] Koval’skaya S, Kozlov N, Kulcitki V, Aricu A, Ungur N. Transformation of sclareol under ritter reaction conditions. Russ. J. Org. (2013) 49.
[9] Tjølsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: An evaluation of the method. Pain. (1992) 51(1): 5-17.
[10] Akbar A, Tariq M, Nisa M. Pharmacological studies on Salvia haematodes Wall. Acta Trop. (1985) 42 (4): 371–374.
[11] Ustun O, Sezik E. Analgesic Activity of Salvia wiedemannii Boiss. Used in Turkish folk medicine. Rec. Nat. Prod. (2011) 5: 328-331.
[12] Amabeoku GJ, Eagles P, Scott G, Mayeng I, Springfield E. Analgesic and antipyretic effects of Dodonaea angustifolia and Salvia africana-lutea. J. Ethnopharmacol. (2001) 75(2): 117-124.
[13] Meyre-Silva C, Yunes RA, Schlemper V, Campos-Buzzi F, Cechinel-Filho V. Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae). Farmaco. (2005) 60(4): 321-326.
[14] Sun N, Qiu Y, Zhu Y, Liu J, Zhang H, Zhang Q, Yao G. Rhodomicranosides A−I, analgesic diterpene glucosides with diverse carbon skeletons from Rhododendron micranthum. Phytochemistry. (2019) 158: 1-12.
[15] Sun N, Feng Y, Zhang Q, Liu J, Zhou H, Zhang H, Yao G. Analgesic diterpenoids with diverse carbon skeletons from the leaves of Rhododendron auriculatum. Phytochemistry. (2019) 168: 112113.
[16] Chatter R, Kladi M, Tarhouni S, Maatoug R, Kharrat R, Vagias C, Roussis V. Neorogioltriol: A brominated diterpene with analgesic activity from Laurencia glandulifera. Phytochem. Lett. (2009) 2(1): 25-28.
[17] Hernandez-Perez M, Rabanal RM, De La Torre M C, Rodriguez B. Analgesic, anti-inflammatory, antipyretic and haematological effects of aethiopinone, an o-naphthoquinone diterpenoid from Salvia aethiopis roots and two hemisynthetic derivatives. Planta. Med. (1995) 61(6): 505-509.
[18] Wu PC, Chuo WH, Lin SC, Lehman CW, Lien CZ, Wu CS, Lin CC. Sclareol attenuates the development of atopic dermatitis induced by 2,4-dinitrochlorobenzene in mice. Immunopharmacol. Immunotoxicol. (2019) 41(1): 109-116.
[19] Noori S, Hassan ZM, Mohammadi M, Habibi Z, Sohrabi N, Bayanolhagh S. Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo. Cell Immunol. (2010) 263(2): 148-153.
[20] Mahaira LG, Tsimplouli C, Sakellaridis N, Alevizopoulos K, Demetzos C, Han Z, Dimas K. The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action. Eur. J. Pharmacol. (2011) 666(1): 173-182.
[21] Borges GSM, Silva JdO, Fernandes RS, de Souza ÂM, Cassali GD, Yoshida MI, Ferreira LAM. sclareol is a potent enhancer of doxorubicin: Evaluation of the free combination and co-loaded nanostructured lipid carriers against breast cancer. Life. Sci. (2019) 232: 116678.
[22] Dimas K, Kokkinopoulos D, Demetzos C, Vaos B, Marselos M, Malamas M, Tzavaras T. The effect of sclareol on growth and cell cycle progression of human leukemic cell lines. Leuk. Res. (1999) 23(3): 217-234.
[23] Campos DR, Celotto AC, Albuquerque AAS, Ferreira LG, Monteiro A, Coelho EB, Evora PRB. The diterpene sclareol vascular effect in normotensive and hypertensive rats. Arq. Bras Cardiol. (2017) 109(2): 117-123.
[24] Park JE, Lee KE, Jung E, Kang S, Kim YJ. Sclareol isolated from Salvia officinalis improves facial wrinkles via an antiphotoaging mechanism. J. Cosmet. Dermatol. (2016) 15(4): 475-483.
[25] Crusco A, Whiteland H, Baptista R, Forde-Thomas JE, Beckmann M, Mur LAJ, Hoffmann KF. Antischistosomal properties of sclareol and its heck-coupled derivatives: Design, synthesis, biological evaluation, and untargeted metabolomics. ACS Infect. Dis. (2019) 5(7): 1188-1199.
[26] Tsai SW, Hsieh MC, Li S, Lin SC, Wang SP, Lehman CW, Lin CC. Therapeutic potential of sclareol in experimental models of rheumatoid arthritis. Int. J. Mol. Sci. (2018) 19 (5): 1351.
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