Fluorimetric Methods for the Determination of Terazosin HCl in Drug Substance and Dosage Forms Fingerprinting and Anti-diabetic analysis of alcoholic and aqueous stem extracts B. tomentosa
Iranian Journal of Pharmaceutical Sciences,
Vol. 10 No. 1 (2014),
15 January 2014
,
Page 15-26
https://doi.org/10.22037/ijps.v10.40831
Abstract
Determination of terazosin hydrochloride dihydrate (TRZ) in drug substance and tablets was studied by fluorimetric techniques. The fluorimetric methods are based on: (1) measurement of the native fluorescence of the drug in water at 750 nm after excitation at 330 nm. (2) sensitizing the native fluorescence by formation a binary complex of drug with aqueous uranyl acetate (0.1% w/v) at the same Ex / Em. under the described condition. the proposed methods were applicable over the concentration range of (10 -1000 and 0.5-12 ng mL-1) with good correlation ((r2=0.9982 and 0.9987), limit of detection of ( 3.47 and 0.198 ng/mL) and a lower limit of quantification of (10.5 and 0.6 ng mL-1) for method (1) and (2), respectively. The described methods were successfully applied for the determination of TRZ in its commercial tablets without interference from common excipients.
Keywords:
- fluorimetric determination
- sensitizing the native fluorescence
- Terazosin HCl
- uranyl acetate
How to Cite
Taghreed A. Mohamed, & Nahla S.Ismail. (2014). Fluorimetric Methods for the Determination of Terazosin HCl in Drug Substance and Dosage Forms: Fingerprinting and Anti-diabetic analysis of alcoholic and aqueous stem extracts B. tomentosa. Iranian Journal of Pharmaceutical Sciences, 10(1), 15–26. https://doi.org/10.22037/ijps.v10.40831
References
[1] British Pharmacopia (BP), Her Majesty,s Stationary Office London (2011).
[2] Sekhar E C, Rao T R, Sekhar K R, Naidu M U, Shobha J C, Rani, P U, Kumar TV, Kumar V P. Determination of terazosin in human plasma using high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B, (1998) (710) 137-142.
[3] Patterson SE. Determination of terazosin in human plasma using high-performance liquid chromatography with fluorescence detection. J. Chromatogr B, (1984) (311)206-212.
[4] Bhamra R K, Flanagan R J, Holt D W, High-performance liquid chromatographic measurement of prazosin and terazosin in biological fluids. J. Chromatogr B, (1986) (380) 216-221.
[5] Zavitsanos A P, Tanja A K, Enantioselective determination of terazosin in human plasma by normal phase high-performance liquid chromatography–electrospray mass spectrometry J. Chromatogr A, , (1998) (794) 45-56.
[6] Bakshi M, Ojha T. Singh S, Validated specific HPLC methods for determination of prazosin, terazosin and doxazosin in the presence of degradation products formed under ICH-recommended stress conditions J. Pharm. Biomed. Anal. (2004) (34) 19.
[7] Raul A S, Adriana N M, X-ray spectrometry (2007) (36) 279.
[8]. Rao J V, Reddy G K, Jayasree V, Chowdary K P R. Spectrophotometric Method For The Determination Of Terazosin Indian J. Pharm. Sci. (2001) (63) 164-165.
[9] Sarsambi P S, Kapse G K, Raju S A. Visible Spectrophotometric Determination of Terazosin Hydrochloride from Bulk Drug and Formulations.Asian J. Chem., (2002) (14) 545-547.
[10] Sarsambi P S, Kapse G K, Shobha. M, Raju S A., Spectrophotometric determination of terazosin hydrochloride Asian J. Chem., (2000) (12), 1325-1326
[11] Sankar V, Raghuraman S, Sivan V, Ravichandran V. Spectrophotometric Method for the Estimation of Terazosin In Tablets Ind. J.Pharm. Sci., (2000) (62) 463-464.
[12] Abdine H H, El-Yazbi F A, Blaih S M, Shaalan R A , Spectrophotometric and spectrofluorimetric methods for the determination of terazosin in dosage forms. Spectroscopy Lett, (1998) (31), 969-980.
[13] Sarsambi P S, Raju S A. Spectrophotometric determination of terazosin hydrochloride,Asian J. Chem (2001) (13) 760-762.
[14] Detroyer A; Schoonjans V, Questier F; Vander-Heyden Y, Borosy A.P, Guo Q, Massart DL. J-Chromatogr,-A. chromatography,-liquid,-high-performance-(HPLC)-C: in classification of drugs 897(1-2) (2000) 23-36
[15] Ren, X Q. Don g Y Y, Huang A J,.Sun YmL,. Sun Z P .Separation of the enantiomers of four chiral drugs by neutral cyclodextrin-mediated capillary zone electrophoresis. J Chromatographia. (1999) 49(7-8) 411-414
[16] Ganjali M R., Faridbod F, Larijani B,. Riahi S, Hosseini M, Nasli-Esfahani E, Norouzi P. Terazosin Potentiometric Sensor for Quantitative Analysis of Terazosin Hydrochloride in Pharmaceutical Formulation Based on Computational Study. Int. J. Electrochem. Sci., (2010) (5) 200 – 214
[17] Ghoneim, M M, el-Ries, M A, HammamE,Beltagi, A M. A validated stripping voltammetric procedure for quantification of the anti-hypertensive and benign prostatic hyperplasia drug terazosin in tablets and human serum. Talanta. 20 Oct (2004) 64(3): 703-710
[18] Jiang C Q, Gao M X, He J X. Study of the interactions between terazosin and serum albumin. Synchronous fluorescence determination of terazosin. Anal.Chim-Acta. 11 Feb (2002); 452(2) 185-189
[19] Taha EA. Yaowu Fenxi Zahi. (2004) 24(4) 390-394
[20] Guzi A A. Qamar S. Atta MA Spectrochim Acta Part B. (1994) 49(5) 527-531
[21] Wronski M. Quenching and liquid chromatographic determination of polythionates in natural water. J Chem Anal (1987) 32(3): 315-318
[22] Taha E A, Hassan N Y, Abdel Aal F., AND Abdel Fattah LE. Different methodologies For the Determination of Thioctic Acid in bulk Powder and in Pharmacutical Formulations. Bull.Fac. Pharm.Cairo Univ. (2008) (46) (3) 201-211.
[23] Tian. J, Li. C, Liu. S, Liu. Z, Zhu. J, hu. x and Yang. J Anal. Methods, (2014)e liquid chromatographic measurement of prazosin and terazosin in biological fluids. J. Chromatogr B, (1986) (380) 216-221.
[24]..Zh. G, hen. C,.Huang. X, Zheng. Zh.Zh, .Xu; J.G,.Wang Z.B. (1990) Method of Fluorescence Analysis, 2 nd ed, Science Press: Beijing, 17.
[25].Lakowicz. J “Principles of Fluorescence Spectroscopy Position”. Plenum Press, New York (1983), Pp 187-215
[26]. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Harmonized Tripartite Guideline. Validation of Analytical Procedures: Text and Methodology, Q2 (R1). Complementary Guideline on Methodology dated, 6 November 1996, London, incorporated in November 2005.
[27] Christian G. D, Analytical Chemistry, John Wiley, USA (1994).
[2] Sekhar E C, Rao T R, Sekhar K R, Naidu M U, Shobha J C, Rani, P U, Kumar TV, Kumar V P. Determination of terazosin in human plasma using high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B, (1998) (710) 137-142.
[3] Patterson SE. Determination of terazosin in human plasma using high-performance liquid chromatography with fluorescence detection. J. Chromatogr B, (1984) (311)206-212.
[4] Bhamra R K, Flanagan R J, Holt D W, High-performance liquid chromatographic measurement of prazosin and terazosin in biological fluids. J. Chromatogr B, (1986) (380) 216-221.
[5] Zavitsanos A P, Tanja A K, Enantioselective determination of terazosin in human plasma by normal phase high-performance liquid chromatography–electrospray mass spectrometry J. Chromatogr A, , (1998) (794) 45-56.
[6] Bakshi M, Ojha T. Singh S, Validated specific HPLC methods for determination of prazosin, terazosin and doxazosin in the presence of degradation products formed under ICH-recommended stress conditions J. Pharm. Biomed. Anal. (2004) (34) 19.
[7] Raul A S, Adriana N M, X-ray spectrometry (2007) (36) 279.
[8]. Rao J V, Reddy G K, Jayasree V, Chowdary K P R. Spectrophotometric Method For The Determination Of Terazosin Indian J. Pharm. Sci. (2001) (63) 164-165.
[9] Sarsambi P S, Kapse G K, Raju S A. Visible Spectrophotometric Determination of Terazosin Hydrochloride from Bulk Drug and Formulations.Asian J. Chem., (2002) (14) 545-547.
[10] Sarsambi P S, Kapse G K, Shobha. M, Raju S A., Spectrophotometric determination of terazosin hydrochloride Asian J. Chem., (2000) (12), 1325-1326
[11] Sankar V, Raghuraman S, Sivan V, Ravichandran V. Spectrophotometric Method for the Estimation of Terazosin In Tablets Ind. J.Pharm. Sci., (2000) (62) 463-464.
[12] Abdine H H, El-Yazbi F A, Blaih S M, Shaalan R A , Spectrophotometric and spectrofluorimetric methods for the determination of terazosin in dosage forms. Spectroscopy Lett, (1998) (31), 969-980.
[13] Sarsambi P S, Raju S A. Spectrophotometric determination of terazosin hydrochloride,Asian J. Chem (2001) (13) 760-762.
[14] Detroyer A; Schoonjans V, Questier F; Vander-Heyden Y, Borosy A.P, Guo Q, Massart DL. J-Chromatogr,-A. chromatography,-liquid,-high-performance-(HPLC)-C: in classification of drugs 897(1-2) (2000) 23-36
[15] Ren, X Q. Don g Y Y, Huang A J,.Sun YmL,. Sun Z P .Separation of the enantiomers of four chiral drugs by neutral cyclodextrin-mediated capillary zone electrophoresis. J Chromatographia. (1999) 49(7-8) 411-414
[16] Ganjali M R., Faridbod F, Larijani B,. Riahi S, Hosseini M, Nasli-Esfahani E, Norouzi P. Terazosin Potentiometric Sensor for Quantitative Analysis of Terazosin Hydrochloride in Pharmaceutical Formulation Based on Computational Study. Int. J. Electrochem. Sci., (2010) (5) 200 – 214
[17] Ghoneim, M M, el-Ries, M A, HammamE,Beltagi, A M. A validated stripping voltammetric procedure for quantification of the anti-hypertensive and benign prostatic hyperplasia drug terazosin in tablets and human serum. Talanta. 20 Oct (2004) 64(3): 703-710
[18] Jiang C Q, Gao M X, He J X. Study of the interactions between terazosin and serum albumin. Synchronous fluorescence determination of terazosin. Anal.Chim-Acta. 11 Feb (2002); 452(2) 185-189
[19] Taha EA. Yaowu Fenxi Zahi. (2004) 24(4) 390-394
[20] Guzi A A. Qamar S. Atta MA Spectrochim Acta Part B. (1994) 49(5) 527-531
[21] Wronski M. Quenching and liquid chromatographic determination of polythionates in natural water. J Chem Anal (1987) 32(3): 315-318
[22] Taha E A, Hassan N Y, Abdel Aal F., AND Abdel Fattah LE. Different methodologies For the Determination of Thioctic Acid in bulk Powder and in Pharmacutical Formulations. Bull.Fac. Pharm.Cairo Univ. (2008) (46) (3) 201-211.
[23] Tian. J, Li. C, Liu. S, Liu. Z, Zhu. J, hu. x and Yang. J Anal. Methods, (2014)e liquid chromatographic measurement of prazosin and terazosin in biological fluids. J. Chromatogr B, (1986) (380) 216-221.
[24]..Zh. G, hen. C,.Huang. X, Zheng. Zh.Zh, .Xu; J.G,.Wang Z.B. (1990) Method of Fluorescence Analysis, 2 nd ed, Science Press: Beijing, 17.
[25].Lakowicz. J “Principles of Fluorescence Spectroscopy Position”. Plenum Press, New York (1983), Pp 187-215
[26]. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Harmonized Tripartite Guideline. Validation of Analytical Procedures: Text and Methodology, Q2 (R1). Complementary Guideline on Methodology dated, 6 November 1996, London, incorporated in November 2005.
[27] Christian G. D, Analytical Chemistry, John Wiley, USA (1994).
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