Antibacterial Activity of Some New Azole Compounds Antibacteria activity of azole compounds
Iranian Journal of Pharmaceutical Sciences,
Vol. 8 No. 4 (2012),
1 Mehr 2012
,
Page 267-270
https://doi.org/10.22037/ijps.v8.40928
Abstract
We have previously synthesized new N-alkylated azoles (1b-7b) as antifungal agents. Here, we evaluated the antibacterial activities of these compounds against two gram positive and two gram negative bacteria by broth microdilution method. The aminothiazole derivative (7b) showed an excellent antibacterial activity. Other compounds exhibited moderate to good antibacterial activity. All compounds are more
active against gram positive than against gram negative bacteria.
Keywords:
- Aminothiazole
- Antibacterial
- Benzimidazole
- Benzotriazole.
How to Cite
Hossein Sadeghpour, Zahra Rezaie, Yones Ghasemi, Zahra Falahzadeh, & Soghra Khabnadideh. (2012). Antibacterial Activity of Some New Azole Compounds: Antibacteria activity of azole compounds. Iranian Journal of Pharmaceutical Sciences, 8(4), 267–270. https://doi.org/10.22037/ijps.v8.40928
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[11] Khabnadideh S, Rezaei Z, Pakshir K, Zomorodian K, Ghafari N. Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives. Res Pharm Sci 2012; 7: 65-72.
[2] Sharma PK, Chandak N, Kumar P, Sharma C, Aneja KR. Synthesis and biological evaluation of some 4-functionalized-pyrazoles as antimicrobial agents. Eur J Med Chem 2011; 46: 1425-32.
[3] Sarmah KN, Sarmah NK, Patel TV, Kurmi KB. Synthesis, characterization, antimicrobial studies of certain triazole containing s-triazine derived compound. Internat J Computat Engineering Res
2012; 2: 289-93.
[4] Kutkowska J, Modzelewska-banachiewicz B, Zoilkowska G, Rzeski W, Urbanik-sypniewska T, Zwolska Z, Prus M. Antimicrobial activity of 3,4-disubstituted-1,2,4-triazole. Acta Poloniae Pharm Drug Res 2005; 62: 303-6.
[5] Khalafi-Nezhad A, Soltani Rad MN, Mohabatkar H, Asrari Z, Hemmateenejad B. Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives. Bioorganic & Amp; Med Chem 2005; 13: 1931-8.
[6] Yadav S, Kumar P, De Clercq E, Balzarini J, Pannecouque C, Dewan SK, Narasimhan B. 4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol -2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation. Eur J Med Chem 2010; 45: 5985-97.
[7] Kucukbay H, Yilmaz U, Sireci N, Onganer A.Synthesis and antimicrobial activities of some bridged bis-benzimidazole derivatives. Turk J Chem 2011; 35: 561-71.
[8] Singh N, Pandurangan A, Kavita Rana PA, Ahmad A, Tiwari AK. Benzimidazole a short review of their antimicrobial activities. Internat Current Pharm J 2012; 1: 119-27.
[9] Xu LL, Zheng CJ, Sun LP, Miao J, Piao HR. Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. Eur J Med Chem 2012; 48: 174-8.
[10] Sun QY, Xu JM, Cao YB, Zhang WN, Wu QY, Zhang DZ, Zhang J, Zhao HQ, Jiang YY. Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14-α-demethylase (CYP51). Eur J Med Chem 2007; 42: 1226-33.
[11] Khabnadideh S, Rezaei Z, Pakshir K, Zomorodian K, Ghafari N. Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives. Res Pharm Sci 2012; 7: 65-72.
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