Physico-Mechanical Analysis of Free Ethylcellulose FilmsPlasticized with Incremental Weight Percents of Dibutyl Sebacate Ethylcellulose membranes plasticized with dibutyl sebacate
Iranian Journal of Pharmaceutical Sciences,
Vol. 3 No. 3 (2007),
1 Tir 2007
,
Page 135-142
https://doi.org/10.22037/ijps.v3.41006
Abstract
This research was conducted to investigate the physico-mechanical characteris-tics of the ethylcellulose-based coating membranes plasticized with different weightpercents of dibutyl sebacate. In this experiment, free thin polymer sheetings of thesample formulations, by incorporating incremental weight percents of the plasticizer,were prepared employing a revised casting method of delayed solvent evaporation,whereby similar flat specimens of standard dimensions were subjected to tensileloadings and extensions. The data were analyzed to fairly decide on a moderateconcentration of the plasticizer to provide a rationale explanation of a strong, hard,and tough structure among the specimens. The data revealed that 40% (w/w) of theester results in the toughest structure amongst the similar specimens of the seriesleading to an ultimate toughness of 3.31 mj/m3.
Keywords:
- Dibutyl sebacate
- Ethylcellulose
- Free film
- Plasticizer.
How to Cite
Sogol Kangarlou, & Ismaeil Haririan. (2007). Physico-Mechanical Analysis of Free Ethylcellulose FilmsPlasticized with Incremental Weight Percents of Dibutyl Sebacate: Ethylcellulose membranes plasticized with dibutyl sebacate. Iranian Journal of Pharmaceutical Sciences, 3(3), 135–142. https://doi.org/10.22037/ijps.v3.41006
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[2]Lippold BC, Lippold BH, Sutter BK, Gunder W.Properties of aqueous, plasticizer-containing ethylcellulose dispersions and prepared films in respectto the production of oral extended releaseformulations. Drug Dev Ind Pharm1990; 16:1725-47.
[3]Harris MR, Ghebre-Sellassie I. Aqueouspolymeric coating for modified release oral dosageforms. In: McGinity JW, (editor). Aqueouspolymeric coatings for pharmaceutical dosageforms. 2nd ed., New York: Marcel Dekker , 1997;pp. 81-100.
[4]Leong CW, Newton JM, Basit AW, Podczeck F,Cummings JH, Ring SG. The formation of colonicdigestible films of amylose and ethyl cellulosefrom aqueous dispersions at temperatures below37 °C. Eu J Pharm Sci2002; 54; 291-7.
[5]Crowley MM, Schroeder B, Fredersdorf A, Obara,S, Talarico M, Kucera S, McGinity JW. Physico-chemical properties and mechanism of drugrelease from ethylcellulose matrix tablets preparedby direct compression and hot-melt extrusion.Int J Pharm2004; 269: 509-22.
[6]Eldridge JH, Hammond CJ, Meulbroek JA, StaasJK, Gilley RM, Tice TR. Controlled vaccinerelease in the gut-associated lymphoid tissues. PartI. Orally administered biodegradable microspherestarget the peyer's patches. J Control Rel1990; 11:205-14.
[7]Jalsenjak I, Nicolaidou CF, Nixon JR. Dissolutionfrom tablets prepared using ethylcellulosemicrocapsules. J Pharm Pharmacol 1997; 29:169-72.
[8]Frohoff-Hülsmann MA, Schmitz A, Lippold BC.Aqueous ethylcellulose dispersions containingplasticizers of different water solubility andhydroxypropyl methyl cellulose as coatingmaterial for diffusion pellets, part I: Drug releaserates from coated pellets. Int J Pharm1999; 177:69-82.
[9]Frohoff-Hülsmann MA, Lippold BC, McGinityJW. Aqueous ethylcellulose dispersions containingplasticizers of different water solubility andhydroxypropyl methyl cellulose as coatingmaterial for diffusion pellets, part II: Propertiesof sprayed films. Eur J Pharm Biopharm1999;48: 67-75.
[10]Lecomte F, Siepmann J, Walther M, MacRae RJ,Bodmeier R. Polymer blends used for the coatingof multi-particulates: Comparison of aqueousand organic coating techniques. Pharm Res2004;21: 882-90. [11]Lecomte F, Siepmann J, Walther M, MacRae RJ,Bodmeier R. Polymer blends used for the aqueouscoating of solid dosage forms: Importance of thetype of plasticizer. J Control Rel 2004; 99: 1-13.
[12]Wheatley TA, Steuernagel CR. Latex emulsionsfor controlled drug delivery. In: McGinity JW,(editor). Aqueous polymeric coatings forpharmaceutical dosage forms, 2nded., New York:Marcel Dekker, 1997; pp. 1-54.
[13]Bodmeier R, Paeratakul O. Mechanical propertiesof dry and wet cellulosic and acrylic filmsprepared from aqueous colloidal polymerdispersions used in the coating of solid dosageforms. Pharm Res1994; 11: 882-8.
[14]Bodmeier R, Paeratakul O. Process andformulation variables affecting the drug releasefrom chlorpheniramine maleate-loaded beadscoated with commercial and self-prepared aqueousethyl cellulose pseudolatexes.Int J Pharm1991;70: 59-68.
[15]Nesbitt RU. Effect of formulation components ondrug release from multi particulates. Drug Dev IndPharm1994; 20: 3207-36.
[16]Ozturk AG, Ozturk, SS, Palsson BO, WheatleyTA, Dressman JB. Mechanism of release frompellets coated with an ethylcellulose-based film.J Control Rel1990; 14: 293-304.
[17]Lippold BH, Sutter BK, Lippold BC. Parameterscontrolling drug release from pellets coated withaqueous ethylcellulose dispersion. Int J Pharm1989; 54: 15-25.
[18]Gutiérrez-Rocca JC, McGinity JW. Influence ofwater soluble and insoluble plasticizers on the physical and mechanical properties of acrylicresin copolymers. Int J Pharm1994; 103: 293-301.
[19]Hyppolo R, Husson I, Sundholm F. Evaluation ofphysical properties of plasticized ethyl cellulosefilms cast from ethanol solution. Part I. Int JPharm1996; 133: 161-70.
[20]Fetscher A, Schmidt PC. Influence of water-soluble and water-insoluble plasticizers on thethermal and mechanical properties ofmethacrylate-copolymer films. Pharm Ind1999;61: 69-73.
[21]Wade A, Weller PJ.Hand book of pharmaceuticalexcipients. 2nded., Washington: AmericanPharmaceutical Association, 1994; pp. 186-90.
[22]Clarke LD. Plane and geodetic surveying forengineers - plane surveying. Vol. 1. 6thed., Delhi:CBS Publishers and Distributors, 1983; pp. 33-7.
[23]Geres JM, Timoshenko SP. Mechanics ofmaterials. 3rded. Boston: PWS-KENTPublishingCompany, 1990; (a) pp. 116-25, (b) pp. 3-27.
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