Development and Application of a Validated LiquidChromatography-Mass Spectrometry Method fortheDetermination of Dexchlorpheniramine Maleate in Human Plasma Determination of dexchlorpheniramine
Iranian Journal of Pharmaceutical Sciences,
Vol. 3 No. 3 (2007),
1 July 2007
,
Page 161-170
https://doi.org/10.22037/ijps.v3.41015
Abstract
Aconvenient liquid chromatographic-single Quadrupole mass spectrometric(LC-MS) method was developed and validated for dexchlorpheniramine maleate (INNname: chlorphenamine) determination in human plasma. The need for just a singleliquid-liquid extraction with ethyl acetate and being highly sensitive were theadvantages of this method. The linearity was also excellent over the range of 1 to150 ng.ml-1of dexchlorpheniramine maleate concentration. The method wasstatistically validated for its selectivity, linearity, precision and robustness. This methodwas successfully applied to the analysis of chlorpheniramine maleate in clinicalstudies.
- Bioequivalence
- Dexchlorpheniramine maleate
- LC-MS
How to Cite
References
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