Studies on the Synthesis of Novel 2,4-ThiazolidinedioneDerivatives with Antidiabetic Activity Synthesis of 2,4-thiazolidinedione derivatives
Iranian Journal of Pharmaceutical Sciences,
Vol. 5 No. 4 (2009),
1 October 2009
,
Page 225-230
https://doi.org/10.22037/ijps.v5.41227
Abstract
A new series of thiazolidinedione derivatives were synthesized. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All of the compounds were screened for antidiabetic activity on albino rats.Most of the compounds showed significant antidiabetic activity when compared with the standard drug glibenclamide.
Keywords:
- Antidiabetic activity
- Microwave assisted synthesis
- Thiazolidinedione
How to Cite
Shashikant R. Pattan, Prajact Kekare, Ashwini Patil, Ana Nikalje, & BS Kittur. (2009). Studies on the Synthesis of Novel 2,4-ThiazolidinedioneDerivatives with Antidiabetic Activity: Synthesis of 2,4-thiazolidinedione derivatives. Iranian Journal of Pharmaceutical Sciences, 5(4), 225–230. https://doi.org/10.22037/ijps.v5.41227
References
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[10]Pattan SR, Khade AB, Pawar PD, Tarnalli AD,Kittur BS, Borkar SD. Synthesis of 2-amino [5'-(4-sulphonyl benzylidene)-2, 4-thiazolidinedione]-6-fluro benzothiazoles as antiinflammatory agents. Indian J Heterocyclic Chem2007; 16:299-300.
[11]Pattan SR, Suresh Ch, Pujar VD, Reddy VVK,Rasal VP, Koti BC. Synthesis and antidiabetic activity of 2-amino [5 (4-sulphonylbenzylidine)-2,4-thiazolidinedione]-7-chloro-6-fluorobenzothia zole. Indian J Chem2005; 44B: 2404-8.
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[2]Turner N C. Drug discovery today. London:Elsevier, 1996; p. 109.
[3]Lebovitz HE. Clinician's manual on insulin resistance. London: London Science press LTD,2002; p. 162.
[4]Groop L, Orho-Melender M. The dymetabolic syndrome. J Intern Med2001; 250: 105-20.
[5]De Fronzo RA, Bonadonna RC., Ferrannini E.Pathogenesis of NIDDM. Abalanced overview.Diabetes Care1992; 15: 318-68.
[6]Xiao-Wen S, Xin-Ping H, Chang-Hu C and Zi-YiZ. Syntheses of Thiazolo [2,3-c]-s-triazoles Using Poly[(4-diacetoxyiodo) styrene]. Indian J Chem 2001; 40B: 15-18.
[7]Dhiman AM, Wadodkar KN. Syntheses and antidiabetic activity of Thiazolidinedione derivatives. Indian J Chem2001; 40B: 636-8.
[8]Nathan DM. Clinical practice. Initial management of glycemia in type 2 diabetes mellitus. N Engl J Med2002; 347; 1342-9.
[9]Day C. Thiazolidinediones: Anew class of antidiabetic drugs. Diabetic Med1999; 16: 1-14.
[10]Pattan SR, Khade AB, Pawar PD, Tarnalli AD,Kittur BS, Borkar SD. Synthesis of 2-amino [5'-(4-sulphonyl benzylidene)-2, 4-thiazolidinedione]-6-fluro benzothiazoles as antiinflammatory agents. Indian J Heterocyclic Chem2007; 16:299-300.
[11]Pattan SR, Suresh Ch, Pujar VD, Reddy VVK,Rasal VP, Koti BC. Synthesis and antidiabetic activity of 2-amino [5 (4-sulphonylbenzylidine)-2,4-thiazolidinedione]-7-chloro-6-fluorobenzothia zole. Indian J Chem2005; 44B: 2404-8.
[12]Smitha N, Garg SP, Pramilla S. Synthesis char-acterization and biological evaluation of certain substituted Thiazolidinediones. Indian J Heterocy Ch2002; 12: 9-14.
[13]Gale EA. Lessons from the glitazones: Astory of drug development. Lancet2001; 357: 1870-5.
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