Pharmaceutical Nanoemulsions and Their Potential Topical and Transdermal Applications Pharmaceutical nanoemulsions potential applications
Iranian Journal of Pharmaceutical Sciences,
Vol. 7 No. 3 (2011),
1 July 2011
,
Page 139-150
https://doi.org/10.22037/ijps.v7.41311
Abstract
Topical and transdermal drug delivery systems are noninvasive and can be self-administered with the minimization of side-effects, have received increased attention during the past few years. Nanoemulsions, emulsions sized between 20-200 nm with narrow distributions, offer several advantages for topical and transdermal delivery of pharmaceutical agents including controlled droplet size, the ability to efficiently dissolve lipophilic drugs, enhanced skin permeation and extended release of lipophilic and hydrophilic drugs. Moreover, they exert good sensorial and physical properties such as complete dispersion on skin and skin hydration in cosmetic products. The review deals with nanoemulsion applications in topical and transdermal
drug and gene delivery.
Keywords:
- Drug Delivery
- Nanoemulsion
- Nanotechnology;
- Skin
- Topical;
- Transdermal.
How to Cite
Samira Sadat Abolmaali, Ali Mohammad Tamaddon, Fakhr Sadat Farvadi, Saeed Daneshamuz, & Hamidreza Moghimi. (2011). Pharmaceutical Nanoemulsions and Their Potential Topical and Transdermal Applications: Pharmaceutical nanoemulsions potential applications . Iranian Journal of Pharmaceutical Sciences, 7(3), 139–150. https://doi.org/10.22037/ijps.v7.41311
References
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[26] Kuo F, Subramanian B, Kotyla T, Wilson TA, Yoganathan S, Nicolosi RJ. Nanoemulsions of an antioxidant synergy formulation containing tocopherol have enhanced bioavailability and anti-inflammatory properties. Int J Pharm 2008;363: 206-13.
[27] Subramanian B, Kuo F, Ada E. Enhancement of anti-inflammatory property of aspirin in mice by a nano-emulsion preparation. Int Immunopharmacol 2008; 8: 1533-9.
[28] Sakeena MH, Elrashid SM, Muthanna FA, Ghassan ZA, Kanakal MM, Laila L, Munavvar AS, Azmin MN. Effect of limonene on permeation enhancement of ketoprofen in palm oil esters nanoemulsion. J Oleo Sci 2010; 59: 395-400.
[29] Sakeena MH, Muthanna FA, Ghassan ZA, Kanakal MM, Elrashid SM, Munavvar AS, Azmin MN. Formulation and in vitro evaluation of ketoprofen in palm oil esters nanoemulsion for topical delivery. J Oleo Sci 2010; 59: 223-8.
[30] Sakeena MH, Yam MF, Elrashid SM, Munavvar AS, Azmin MN. Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion. J Oleo Sci 2010; 59: 667-71.
[31] Kim BS, Won M, Lee KM, Kim CS. In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug. Drug Deliv 2008; 15:465-9.
[32] Baboota S, Shakeel F, Ahuja A, Ali J, Shafiq S.Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharm 2007; 57: 31532.
[33] Wang X., Jiang Y, Wang Y, Huang M, Ho C, Huang Q. Enhancing anti-inflammation activity of curcumin through o/w nanoemulsions. Food Chem 2008; 108: 419-24.
[34] Hoeller S, Sperger A, Valenta C. Lecithin based nanoemulsions: a comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour
and skin permeation. Int J Pharm 2009; 370:181-6.
[35] Klang V, Matsko N, Raupach K, El-Hagin N, Valenta C. Development of sucrose stearate-based nanoemulsions and optimisation through gammacyclodextrin.Eur J Pharm Biopharm 2011; 79: 58-67.
[36] Klang V, Matsko N, Zimmermann AM,Vojnikovic E, Valenta C. Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions. Int J Pharm 2010; 393: 152-60.
[37] Stecova J, Mehnert W, Blaschke T, Kleuser B, Sivaramakrishnan R, Zouboulis CC, Seltmann H, Korting HC, Kramer KD, Schafer-Korting M.Cyproterone acetate loading to lipid nanoparticles
for topical acne treatment: particle characterisation and skin uptake. Pharm Res 2007; 24:991-1000.
[38] Tagne JB, Kakumanu S, Nicolosi RJ.Nanoemulsion preparations of the anticancer drug dacarbazine significantly increase its efficacy in a xenograft mouse melanoma model. Mol Pharm 2008; 5: 1055-63.
[39] Kakumanu S, Tagne JB, Wilson TA, Nicolosi RJ. A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension. Nanomedicine 2011; 7:277-83.
[40] Alves MP, Scarrone AL, Santos M, Pohlmann AR, Guterres SS. Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers. Int J Pharm 2007; 341:215-20.
[41] Alves PM, Pohlmann AR, Guterres SS. Semisolid topical formulations containing nimesulide-loaded nanocapsules, nanospheres or nanoemulsion: development and rheological characterization.
Pharmazie 2005; 60: 900-4.
[42] Fontana MC, Coradini K, Guterres SS, Pohlmann AR, Beck RC. Nanoencapsulation as a way to control the release and to increase the photostability of clobetasol propionate: influence of the nanostructured system. J Biomed Nanotechnol 2009; 5: 254-63.
[43] Fontana MC, Rezer JF, Coradini K, Leal DB, Beck RC. Improved efficacy in the treatment of contact dermatitis in rats by a dermatological nanomedicine containing clobetasol propionate.Eur J Pharm Biopharm 2011; 79: 241-9.
[44] Wang JJ, Hung CF, Yeh CH, Fang JY. The release and analgesic activities of morphine and its ester prodrug, morphine propionate, formulated by water-in-oil nanoemulsions. J Drug Target 2008;
16: 294-301.
[45] Silva AP, Nunes BR, De Oliveira MC, Koester LS, Mayorga P, Bassani VL, Teixeira HF.Development of topical nanoemulsions containing the isoflavone genistein. Pharmazie 2009; 64:32-5.
[46] Wu H, Ramachandran C, Bielinska AU, Kingzett K, Sun R, Weiner ND, Roessler BJ. Topical transfection using plasmid DNA in a water-in-oil nanoemulsion. Int J Pharm 2001; 221: 23-34.
[47] Zhang LW, Al-Suwayeh SA, Hung CF, Chen CC,Fang JY. Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions. Int J Nanomedicine 2011; 6: 693704.
[48] Dirschka T, Radny P, Dominicus R, Mensing H, Bruning H, Jenne L, Karl L, Sebastian M, OsterSchmidt C, Klovekorn W, Reinhold U, Tanner M, Grone D, Deichmann M, Simon M, Hubinger F, Hofbauer
G, Krahn-Senftleben G, Borrosch F, Reich K, Berking C, Wolf P, Lehmann P, MoersCarpi M, Honigsmann H, Wernicke-Panten K, Helwig C, Foguet M, Schmitz B, Lubbert H, Szeimies RM. Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison to a registered methyl-aminolaevulinic acid cream and placebo. Br J Dermatol 2012;166:137-46.
[49] Primo FL, Bentley MV, Tedesco AC.Photophysical studies and in vitro skin permeation/retention of foscan/nanoemulsion (NE) applicable to photodynamic therapy skin cancer treatment. J Nanosci Nanotechnol 2008;8: 340-7.
[50] Junyaprasert VB, Teeranachaideekul V, Souto EB, Boonme P, Muller RH. Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation. Int J Pharm 2009; 377:207-14.
[51] Mitri K, Shegokar R, Gohla S, Anselmi C, Muller RH. Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance. Int J Pharm 2011; 414: 267-75.
[52] Hamouda T, Hayes MM, Cao Z, Tonda R, Johnson K, Wright DC, Brisker J, Baker JR Jr. A novel surfactant nanoemulsion with broadspectrum sporicidal activity against bacillus species. J Infect Dis 1999; 180: 1939-49.
[53] Hamouda T, Myc A, Donovan B, Shih AY, Reuter JD, Baker JR Jr. A novel surfactant nanoemulsion with a unique non-irritant topical antimicrobial activity against bacteria, enveloped viruses and
fungi. Microbiol Res 2001; 156: 1-7.
[54] Pannu J, McCarthy A, Martin A, Hamouda T, Ciott Si, Fothergill A, Sutcliffe J. NB-002, a novel nanoemulsion with broad antifungal activity against dermatophytes, other filamentous fungi, and Candida albicans. Antimicrob Agents Chemother 2009; 53: 3273-9.
[55] Pannu J, McCarthy A, Martin A, Hamouda T, Ciotti S, Ma L, Sutcliffe J, Baker JR Jr. In vitro antibacterial activity of NB-003 against Propionibacterium acnes. Antimicrob Agents Chemother 2011; 55:
4211-7.
[2] Sarker DK. Engineering of nanoemulsions for drug delivery. Curr Drug Deliv 2005; 2: 297310.
[3] Chiesta M, Garg J, Kang YT, Chen G. Thermal conductivity and viscosity of water-in-oil nanoemulsions. Colloid Surface A 2008; 326:67-72.
[4] Fernandez P, Andre V, Reiger J, Kuhnle A. Nanoemulsion formation by emulsion phase inversion. Colloid Surface A 2004; 251: 53-8.
[5] Dixit N, Kohli K, Baboota S. Nanoemulsion system for the transdermal delivery of a poorly soluble cardiovascular drug. PDA J Pharm Sci Technol 2008; 62: 46-55.
[6] Shakeel F. Criterion for excipients screening in the development of nanoemulsion formulation of three anti-inflammatory drugs. Pharm Dev Technol 2009; 15: 131-8.
[7] Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S. Nanoemulsions as vehicles for transdermal delivery of aceclofenac. AAPS Pharm Sci Tech 2007; 8: E104.
[8] Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. Celecoxib nanoemulsion: skin permeation mechanism and bioavailability assessment. J Drug Target 2008; 16: 733-40.
[9] Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion. J Nanobiotechnology 2008; 6: 8.
[10] Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. Enhanced anti-inflammatory effects of celecoxib from a transdermally applied nanoemulsion. Pharmazie 2009; 64: 258-9.
[11] Shakeel F, Baboota S, Ahuja A, All J, Shafiq S. Skin permeation mechanism of aceclofenac using novel nanoemulsion formulation. Pharmazie 2008; 63: 580-4.
[12] Shakeel F, Faisal MS. Nanoemulsion: a promising tool for solubility and dissolution enhancement of celecoxib. Pharm Dev Technol 2009; 15: 53-6.
[13] Shakeel F, Ramadan W. Transdermal delivery of anticancer drug caffeine from water-in-oil nanoemulsions. Colloids Surf B Biointerfaces 2009; 75: 356-62.
[14] Shakeel F, Ramadan W, Ahmed MA. Investigation of true nanoemulsions for transdermal potential of indomethacin: characterization, rheological characteristics, and ex vivo skin permeation studies. J Drug Target 2009; 17: 435-41.
[15] Shakeel F, Ramadan W, Gargum HM, Singh R.Preparation and in vivo evaluation of indomethacin loaded true nanoemulsions. Sci Pharm 2009; 78: 47-56.
[16] Zheng WW, Zhao L, Wei YM, Ye Y, Xiao SH. Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride. Chem Pharm Bull (Tokyo) 2010; 58: 1015-9.
[17] Tiwari SB, Amiji MM. Nanoemulsion formulations for tumor targeted delivery In: Amiji M.M., Nanothechnology for cancer therapy, 2007: New York: CRC press, pp. 723-40.
[18] Bouchemal K, Briancon S, Couenne F, Fessi H, Tayakout M. Stability studies on colloidal suspensions of polyurethane nanocapsules. J Nanosci Nanotechnol 2006; 6: 3187-92.
[19] Sonneville-Aubrun O, Simonnet JT, L'Alloret F.Nanoemulsions: a new vehicle for skincare products. Adv Colloid Interface Sci 2004; 108109: 145-9.
[20] Yilmaz E, Borchert HH. Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides. Eur J Pharm Biopharm
2005; 60: 91-8.
[21] Yilmaz E, Borchert HH. Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study. Int J Pharm 2006; 307: 232-8.
[22] Zhou H, Yue Y, Liu G, Li Y, Zhang J, Gong Q, Yan Z, Duan M. Preparation and characterization of a lecithin nanoemulsion as a topical delivery system. Nanoscale Res Lett 2009; 5: 224-30.
[23] Patravale VB, Mandawgade SD. Novel cosmetic delivery systems: an application update. Int J Cosmet Sci 2008; 30: 19-33.
[24] Wu H, Ramachandran C, Weiner ND, Roessler BJ. Topical transport of hydrophilic compounds using water-in-oil nanoemulsions. Int J Pharm 2001; 220: 63-75.
[25] Mou D, Chen H, Du D, Mao CH, Wan J, Xu H, Yang X. Hydrogel-thickened nanoemulsion sytem for topical delivery of lipophilic drugs. Int J Pharm 2008; 353: 270-6.
[26] Kuo F, Subramanian B, Kotyla T, Wilson TA, Yoganathan S, Nicolosi RJ. Nanoemulsions of an antioxidant synergy formulation containing tocopherol have enhanced bioavailability and anti-inflammatory properties. Int J Pharm 2008;363: 206-13.
[27] Subramanian B, Kuo F, Ada E. Enhancement of anti-inflammatory property of aspirin in mice by a nano-emulsion preparation. Int Immunopharmacol 2008; 8: 1533-9.
[28] Sakeena MH, Elrashid SM, Muthanna FA, Ghassan ZA, Kanakal MM, Laila L, Munavvar AS, Azmin MN. Effect of limonene on permeation enhancement of ketoprofen in palm oil esters nanoemulsion. J Oleo Sci 2010; 59: 395-400.
[29] Sakeena MH, Muthanna FA, Ghassan ZA, Kanakal MM, Elrashid SM, Munavvar AS, Azmin MN. Formulation and in vitro evaluation of ketoprofen in palm oil esters nanoemulsion for topical delivery. J Oleo Sci 2010; 59: 223-8.
[30] Sakeena MH, Yam MF, Elrashid SM, Munavvar AS, Azmin MN. Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion. J Oleo Sci 2010; 59: 667-71.
[31] Kim BS, Won M, Lee KM, Kim CS. In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug. Drug Deliv 2008; 15:465-9.
[32] Baboota S, Shakeel F, Ahuja A, Ali J, Shafiq S.Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharm 2007; 57: 31532.
[33] Wang X., Jiang Y, Wang Y, Huang M, Ho C, Huang Q. Enhancing anti-inflammation activity of curcumin through o/w nanoemulsions. Food Chem 2008; 108: 419-24.
[34] Hoeller S, Sperger A, Valenta C. Lecithin based nanoemulsions: a comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour
and skin permeation. Int J Pharm 2009; 370:181-6.
[35] Klang V, Matsko N, Raupach K, El-Hagin N, Valenta C. Development of sucrose stearate-based nanoemulsions and optimisation through gammacyclodextrin.Eur J Pharm Biopharm 2011; 79: 58-67.
[36] Klang V, Matsko N, Zimmermann AM,Vojnikovic E, Valenta C. Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions. Int J Pharm 2010; 393: 152-60.
[37] Stecova J, Mehnert W, Blaschke T, Kleuser B, Sivaramakrishnan R, Zouboulis CC, Seltmann H, Korting HC, Kramer KD, Schafer-Korting M.Cyproterone acetate loading to lipid nanoparticles
for topical acne treatment: particle characterisation and skin uptake. Pharm Res 2007; 24:991-1000.
[38] Tagne JB, Kakumanu S, Nicolosi RJ.Nanoemulsion preparations of the anticancer drug dacarbazine significantly increase its efficacy in a xenograft mouse melanoma model. Mol Pharm 2008; 5: 1055-63.
[39] Kakumanu S, Tagne JB, Wilson TA, Nicolosi RJ. A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension. Nanomedicine 2011; 7:277-83.
[40] Alves MP, Scarrone AL, Santos M, Pohlmann AR, Guterres SS. Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers. Int J Pharm 2007; 341:215-20.
[41] Alves PM, Pohlmann AR, Guterres SS. Semisolid topical formulations containing nimesulide-loaded nanocapsules, nanospheres or nanoemulsion: development and rheological characterization.
Pharmazie 2005; 60: 900-4.
[42] Fontana MC, Coradini K, Guterres SS, Pohlmann AR, Beck RC. Nanoencapsulation as a way to control the release and to increase the photostability of clobetasol propionate: influence of the nanostructured system. J Biomed Nanotechnol 2009; 5: 254-63.
[43] Fontana MC, Rezer JF, Coradini K, Leal DB, Beck RC. Improved efficacy in the treatment of contact dermatitis in rats by a dermatological nanomedicine containing clobetasol propionate.Eur J Pharm Biopharm 2011; 79: 241-9.
[44] Wang JJ, Hung CF, Yeh CH, Fang JY. The release and analgesic activities of morphine and its ester prodrug, morphine propionate, formulated by water-in-oil nanoemulsions. J Drug Target 2008;
16: 294-301.
[45] Silva AP, Nunes BR, De Oliveira MC, Koester LS, Mayorga P, Bassani VL, Teixeira HF.Development of topical nanoemulsions containing the isoflavone genistein. Pharmazie 2009; 64:32-5.
[46] Wu H, Ramachandran C, Bielinska AU, Kingzett K, Sun R, Weiner ND, Roessler BJ. Topical transfection using plasmid DNA in a water-in-oil nanoemulsion. Int J Pharm 2001; 221: 23-34.
[47] Zhang LW, Al-Suwayeh SA, Hung CF, Chen CC,Fang JY. Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions. Int J Nanomedicine 2011; 6: 693704.
[48] Dirschka T, Radny P, Dominicus R, Mensing H, Bruning H, Jenne L, Karl L, Sebastian M, OsterSchmidt C, Klovekorn W, Reinhold U, Tanner M, Grone D, Deichmann M, Simon M, Hubinger F, Hofbauer
G, Krahn-Senftleben G, Borrosch F, Reich K, Berking C, Wolf P, Lehmann P, MoersCarpi M, Honigsmann H, Wernicke-Panten K, Helwig C, Foguet M, Schmitz B, Lubbert H, Szeimies RM. Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison to a registered methyl-aminolaevulinic acid cream and placebo. Br J Dermatol 2012;166:137-46.
[49] Primo FL, Bentley MV, Tedesco AC.Photophysical studies and in vitro skin permeation/retention of foscan/nanoemulsion (NE) applicable to photodynamic therapy skin cancer treatment. J Nanosci Nanotechnol 2008;8: 340-7.
[50] Junyaprasert VB, Teeranachaideekul V, Souto EB, Boonme P, Muller RH. Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation. Int J Pharm 2009; 377:207-14.
[51] Mitri K, Shegokar R, Gohla S, Anselmi C, Muller RH. Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance. Int J Pharm 2011; 414: 267-75.
[52] Hamouda T, Hayes MM, Cao Z, Tonda R, Johnson K, Wright DC, Brisker J, Baker JR Jr. A novel surfactant nanoemulsion with broadspectrum sporicidal activity against bacillus species. J Infect Dis 1999; 180: 1939-49.
[53] Hamouda T, Myc A, Donovan B, Shih AY, Reuter JD, Baker JR Jr. A novel surfactant nanoemulsion with a unique non-irritant topical antimicrobial activity against bacteria, enveloped viruses and
fungi. Microbiol Res 2001; 156: 1-7.
[54] Pannu J, McCarthy A, Martin A, Hamouda T, Ciott Si, Fothergill A, Sutcliffe J. NB-002, a novel nanoemulsion with broad antifungal activity against dermatophytes, other filamentous fungi, and Candida albicans. Antimicrob Agents Chemother 2009; 53: 3273-9.
[55] Pannu J, McCarthy A, Martin A, Hamouda T, Ciotti S, Ma L, Sutcliffe J, Baker JR Jr. In vitro antibacterial activity of NB-003 against Propionibacterium acnes. Antimicrob Agents Chemother 2011; 55:
4211-7.
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