Pantoprazole oral liquid liposomal formulation: Design and Characterization Pantoprazole oral liquid liposomal formulation
Iranian Journal of Pharmaceutical Sciences,
Vol. 20 Núm. 1 (2024),
8 May 2024
,
Página 61-68
https://doi.org/10.22037/ijps.v20i1.42152
Resumen
Pantoprazole (PPZ) is one of the proton pump inhibitors which is used to prevent the secretion of excess gastric acid in both adults and children. However, it is difficult to use in patients under 5 years of age or elderly patients due to the lack of appropriate liquid formulation. In this study, a liquid liposomal formulation of pantoprazole with improved physicochemical stability has been introduced to facilitate the drug administration in above mentioned patients. Lecithin and cholesterol in different ratios were used to prepare liposomes by the thin-layer hydration method. Optimization studies were performed to find the best formulation. Liposomes were examined for particle size, entrapment efficiency, and stability at ambient temperature. The morphology of liposomes was also investigated by scanning electron microscopy and light microscopy. The release rate of the drug from the liposomal formulation in the aqueous phase was monitored for 24 hours. The results showed more than 60% loading of pantoprazole into the liposomes. The particle size of liposomes decreased with increasing levels of lecithin. Analysis of variance showed a significant difference in drug release within 24 hours. The effects of time, temperature, and light on the apparent instability of the drug were restrained by liposomal formulation and the entrapped drug was more stable compared to the pantoprazole solution. The results of the present study demonstrated that the formulation of pantoprazole in liposomes could provide a new perspective for the treatment of gastric reflux.
- Liposomes
- Pantoprazole
- Gastric reflux
Cómo citar
Citas
Modlin IM, and Sachs G. Acid related diseases: biology and treatment. 2nd Edition (2004) Lippincott Williams & Wilkins. 310-311.
Colin‐Jones DG. The role and limitations of H2‐receptor antagonists in the treatment of gastro‐oesophageal reflux disease. Aliment Pharmacology Ther (1995) 9 (1): 9-14.
Forte JG and Lee HC. Gastric adenosine triphosphatases: a review of their possible role in HCl secretion. Gastroenterology (1977) 73(4): 921-926.
Huber R, Kohl B, Sachs G, Senn-Bilfinger J, Simon WA, Sturm E. The continuing development of proton pump inhibitors with particular reference to pantoprazole. Aliment Pharmacol Ther (1995) 9(4): 363-378.
Badwan AA, Nabulsi LN, Omari MM, Daraghmeh NH, Ashour MK, Abdoh AM, et al. Pantoprazole sodium in: Profiles of Drug Substances, Excipients and Related Methodology (2002) V. 29, Academic press, Elsevier Science, USA.
Sharma A, Jain CP. Solid dispersion: A promising technique to enhance solubility of poorly water soluble drug. Int. J. Drug Deliv. (2011) 3(2): 149-170.
Merisko-Liversidge, EM, and Liversidge GG. Drug nanoparticles: Formulating Poorly Water-Soluble Compounds. Toxicol. Pathol. (2008) 36(1): 43-48.
Nayak S, Panda D, Sahoo J. Nanosuspension: A novel drug delivery system. J Pharm Res (2010) 3(2): 241-246.
Jacobs C, Kayser O, Müller RH. Nanosuspensions as a new approach for the formulation for the poorly soluble drug tarazepide. Int. J. Pharm. (2000) 196 (2): 161-164.
Daraee H, Etemadi A, Kouhi M, Alimirzalu S, Akbarzadeh A. Application of liposomes in medicine and drug delivery. Artificial cells, Nanomedicine, and Biotechnology (2014) 44(1): 381-391.
Lila ASA, and Ishida T. Liposomal delivery systems: Design Optimization and Current Applications. Biol. Pharm. Bull (2017) 40(1): 1-10.
Akbarzadeh A, Rezaei-Sadabadi R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, et al. Liposome: classification, preparation, and applications. Nanoscale Research Letters (2013) 8(1); 2-9. DOI: 10.1186/1556-276X-8-102.
Anwekar H, Patel S, and Singhai AK. Liposome-as drug carriers. Int. J. of Pharm. & Life Sci (2011) 2 (7): 945-951
Li M, Du C, Guo N, Teng Y, Meng x, Sun H. Composition design and medical application of liposomes. EJMECH (2019) 164: 640-653.
Dua, JS, Rana AC, Bhandari AK. Liposome: Methods of preparation and applications. Int J Pharm Stud Res (2012) 3 (2): 14-20.
Joshi G, Kumar A, Sawant K. Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. Eur. J. Pharm. Sci (2014) 60: 80-89.
Imura T, Otake K, Hashomoto S, Gotoh T, Yuasa M, Yokoyoma S, et al. Preparation and physicochemical properties of various soybean lecithin liposomes using supercritical reverse phase evaporation method. Colloids Surf. B Biointerfaces (2002) 27: 133-140.
Eloy JO, Souza MC, Petrilli R, Abriata Barcellos JP, Lee RJ, Marchetti JM. Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery. Colloids Surf. B: Biointerfaces (2014) 123: 345-363.
Moghimipour E, Handali S. Liposomes as drug delivery systems: properties and applications. RJPBCS. (2013) 4(1): 169-185.
Handali S, Moghimipour E, Rezaei M, Kouchak M, Ramezani Z, Amini M, et al. New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety. Life Sci. (2019) 227: 39-50.
ElMeshad AN, Mortazavi SM, and Mozafari MR. Formulation and characterization of nanoliposomal 5-fluorouracil for cancer nanotherapy. J Liposome Res. (2013) 24(1): 1-9.
Shigehiro T, Kasai T, Murakami M, Sekhar SC, Tominaga Y, Okada M, et al. Efficient drug delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation. PLoS ONE. (2014) 9(9).
Bahrami B, Hojjat-Farsangi M, Mohammadi H, Anvari E, Ghalamfarsa G, Yousefi M, et al. Nanoparticles and targeted drug delivery in cancer therapy. Immunol. Lett. (2017) 190: 64-83.
Karami N, Moghimipour E, Salimi A. Liposomes as a Novel Drug Delivery System: Fundamental and Pharmaceutical Application. AJP. (2018) (Suppl) • 12 (1) S31.
- Resumen ##plugins.themes.ojsPlusA.frontend.article.viewed##: 9 ##plugins.themes.ojsPlusA.frontend.article.times##
- IJPS_Volume20_Issue1_Pages61-68 (English) ##plugins.themes.ojsPlusA.frontend.article.downloaded##: 8 ##plugins.themes.ojsPlusA.frontend.article.times##