Comparative Pharmacological Potential of Cumin (Cuminum cyminum) Seed Essential Oils: Conventional vs. Superheated Steam Distillation Pharmacological potential of cumin seed oils: Superheated steam vs. conventional extraction techniques
Iranian Journal of Pharmaceutical Sciences,
Vol. 21 No. 1 (2025),
21 January 2025
,
Page 20- 31
https://doi.org/10.22037/ijps.v21i1.44560
Abstract
Cuminum cyminum is a famous spice used worldwide for imparting taste to diverse food provisions, culinary and medicinal purposes, and also for appetizing purposes due to its special aromatic effect. This research work aims to estimate the yield of essential oil (EO), chemical composition, antioxidant and antimicrobial activity of Cuminum cyminum EOs extracted by conventional methods Hydrodistillation (HD) and Steam distillation (SD) towards advanced method Superheated steam distillation (SHSD). SHSD noticed the maximum EO yield compared to the HD and SD methods. Gas chromatography-mass spectrometry (GC-MS) analysis illustrated that Cumin aldehyde (51.87-23.54%) and 3-caren-10-ol (15.34-12.15%) were the most abundant compounds of Cuminum cyminum EOs. Hydrogen peroxide scavenging, ferric-reducing power assay, and DPPH free radical scavenging assay were used to evaluate the antioxidant potential. Results revealed that SHSD EO displayed the highest antioxidant potential compared to HD and SD EOs. The antimicrobial activity was determined using the resazurin microtiter plates test, microdilution broth experiment, and disc diffusion tests contradicting food pathogenic bacterial and fungal strains. SHSD EO observed the highest antimicrobial potential. The results indicated that SHSD is an efficient and excellent method for extracting EOs from Cuminum cyminum seeds, which also engage in biological activities.
- Superheated steam distillation
- Cuminum cyminum
- Essential oil
- Antimicrobial
- Antioxidant potential
How to Cite
References
Fatima, T., S.A. Malik, and A. Shabbir, Hospital healthcare service quality, patient satisfaction and loyalty: An investigation in context of private healthcare systems. International Journal of Quality & Reliability Management, 2018.
Hajlaoui, H., et al., Chemical composition and biological activities of Tunisian Cuminum cyminum L. essential oil: A high effectiveness against Vibrio spp. strains. Food and Chemical Toxicology, 2010. 48(8-9): p. 2186-2192.
Allahghadri, T., et al., Antimicrobial property, antioxidant capacity, and cytotoxicity of essential oil from cumin produced in Iran. Journal of food science, 2010. 75(2): p. H54-H61.
Mnif, S. and S. Aifa, Cumin (Cuminum cyminum L.) from traditional uses to potential biomedical applications. Chemistry & biodiversity, 2015. 12(5): p. 733-742.
Singh, R.P., H. Gangadharappa, and K. Mruthunjaya, Cuminum cyminum–A popular spice: An updated review. Pharmacognosy journal, 2017. 9(3).
Gohari, A.R. and S. Saeidnia, A review on phytochemistry of Cuminum cyminum seeds and its standards from field to market. Pharmacognosy Journal, 2011. 3(25): p. 1-5.
Mughal, S.S., A review on potential antioxidant effects of Cumin (Cuminum cyminum), phytochemical Profile and its uses. Authorea Preprints, 2022.
Agarwal, U., et al., Review on Cuminum Cyminum—nature’s magical seeds. Journal of Chemical and Pharmaceutical Research, 2017. 9(9): p. 180-187.
Allaq, A.A., et al., Cumin (Cuminum cyminum L.): A review of its ethnopharmacology, phytochemistry. Biomedical Research and Therapy, 2020. 7(9): p. 4016-4021.
Parashar, M. and C. Malik, Appraisal of genetic diversity in Cuminum cyminum L. using molecular markers. 2014.
Patra, J.K. and K.-H. Baek, Antibacterial activity and action mechanism of the essential oil from Enteromorpha linza L. against foodborne pathogenic bacteria. Molecules, 2016. 21(3): p. 388.
Gokoglu, N., Novel natural food preservatives and applications in seafood preservation: A review. Journal of the Science of Food and Agriculture, 2019. 99(5): p. 2068-2077.
Hassanien, M.F., et al., Health-promoting value and food applications of black cumin essential oil: an overview. Journal of food science and technology, 2015. 52: p. 6136-6142.
Pokorný, J., Are natural antioxidants better–and safer–than synthetic antioxidants? European journal of lipid science and technology, 2007. 109(6): p. 629-642.
Ayub, M.A., et al., Chemical composition and antimicrobial activity of Boswellia serrata oleo-gum-resin essential oil extracted by superheated steam. Natural Product Research, 2022: p. 1-6.
Xiong, K. and Y. Chen, Supercritical carbon dioxide extraction of essential oil from tangerine peel: Experimental optimization and kinetics modelling. Chemical Engineering Research and Design, 2020. 164: p. 412-423.
Singh, M., S. Patra, and R.K. Singh, Common techniques and methods for screening of natural products for developing of anticancer drugs, in Evolutionary diversity as a source for anticancer molecules. 2021, Elsevier. p. 323-353.
Zhang, J., et al., Recent advances in the extraction of bioactive compounds with subcritical water: A review. Trends in Food Science & Technology, 2020. 95: p. 183-195.
Sadeghmousavi, S., Subcritical water extraction of fennel seeds essential oil and comparison with hydrodistillation. Journal of food science and technology (Iran), 2019. 16(91): p. 119-128.
Masondo, N. and N. Makunga, Advancement of analytical techniques in some South African commercialized medicinal plants: Current and future perspectives. South African Journal of Botany, 2019. 126: p. 40-57.
Yousefi, M., et al., Supercritical fluid extraction of essential oils. TrAC Trends in Analytical Chemistry, 2019. 118: p. 182-193.
Jin, C., et al., Optimization of superheated steam treatment conditions for wheat aleurone layer flour. Food Science and Technology, 2021. 42.
Ayub, M.A., et al., Biological activity of Boswellia serrata Roxb. oleo gum resin essential oil: effects of extraction by supercritical carbon dioxide and traditional methods. International Journal of Food Properties, 2018. 21(1): p. 808-820.
Azeem, M., et al., Pesticidal potential of some wild plant essential oils against grain pests Tribolium castaneum (Herbst, 1797) and Aspergillus flavus (Link, 1809). Arabian Journal of Chemistry, 2022. 15(1): p. 103482.
Rashid, S., et al., Chemical composition, antimicrobial, cytotoxic and antioxidant activities of the essential oil of Artemisia indica Willd. Food chemistry, 2013. 138(1): p. 693-700.
Sarker, S.D., L. Nahar, and Y. Kumarasamy, Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals. Methods, 2007. 42(4): p. 321-324.
Dabur, R., et al., A novel antifungal pyrrole derivative from Datura metel leaves. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2004. 59(7): p. 568-570.
Mensor, L.L., et al., Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytotherapy research, 2001. 15(2): p. 127-130.
Habila, J., et al., Total phenolics and antioxidant activity of Tridax procumbens Linn. African Journal of Pharmacy and Pharmacology, 2010. 4(3): p. 123-126.
Bakkali, F., et al., Biological effects of essential oils–a review. Food and chemical toxicology, 2008. 46(2): p. 446-475.
Abbdellaoui, M., E.d.T. Bouhlali, and L.E. Rhaffari, Chemical composition and antioxidant activities of the essential oils of cumin (Cuminum cyminum) conducted under organic production conditions. Journal of Essential Oil Bearing Plants, 2019. 22(6): p. 1500-1508.
Hajib, A., et al., Chemical composition and biological activities of essential oils from the fruits of Cuminum cyminum L. and Ammodaucus leucotrichus L.(Apiaceae). Journal of Essential Oil Bearing Plants, 2020. 23(3): p. 474-483.
Ghannay, S., et al., In vitro and in silico screening of anti-Vibrio spp., antibiofilm, antioxidant and anti-quorum sensing activities of Cuminum cyminum L. Volatile oil. Plants, 2022. 11(17): p. 2236.
Karik, U., et al., Comparative study on yields, chemical compositions, antioxidant and antimicrobial activities of cumin (Cuminum cyminum l.) seed essential oils from different geographic origins. Journal of Essential Oil Bearing Plants, 2021. 24(4): p. 724-735.
Petretto, G., et al., Chemical composition and antimicrobial activity of essential oils from Cuminum cyminum L. collected in different areas of Morocco. Food bioscience, 2018. 22: p. 50-58.
Ayub, M.A., et al., Comparison of conventional extraction techniques with superheated steam distillation on chemical characterization and biological activities of Syzygium aromaticum L. essential oil. Separations, 2023. 10(1): p. 27.
Moghaddam, M., et al., Variation in essential oil composition and antioxidant activity of cumin (Cuminum cyminum L.) fruits during stages of maturity. Industrial Crops and Products, 2015. 70: p. 163-169.
Sowbhagya, H., B.S. Rao, and N. Krishnamurthy, Evaluation of size reduction and expansion on yield and quality of cumin (Cuminum cyminum) seed oil. Journal of food engineering, 2008. 84(4): p. 595-600.
Shrivastava, A., Steam Distillation: Principle and Applications for the Extraction of Essential Oils from Plants, in Bioprospecting of Tropical Medicinal Plants. 2023, Springer. p. 893-903.
Wongkattiya, N., et al., Antibacterial activity of cuminaldehyde on food-borne pathogens, the bioactive component of essential oil from Cuminum cyminum L. collected in Thailand. Journal of Complementary and Integrative Medicine, 2019. 16(4).
Mostafa, A.A., et al., Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi journal of biological sciences, 2018. 25(2): p. 361-366.
Guo, Y.-R., et al., Effect of drying methods on chemical composition and biological activity of essential oil from Cumin (Cuminum cyminum L.). Journal of Essential Oil Bearing Plants, 2018. 21(5): p. 1295-1302.
Al-Snafi, A.E., The pharmacological activities of Cuminum cyminum-A review. IOSR Journal of Pharmacy, 2016. 6(6): p. 46-65.
Hu, L., et al., Inhibition of p-isopropyl benzaldehyde and p-isopropyl benzoic acid extracted from Cuminum cyminum against plant pathogens. Acta Bot. Boreal. Occident. Sin, 2008. 11: p. 42.
Wanner, J., et al., Chemical composition and antimicrobial activity of cumin oil (Cuminum cyminum, Apiaceae). Natural product communications, 2010. 5(9): p. 1934578X1000500904.
Mahmoudi, R., A. Ehsani, and P. Zare, Phytochemical, antibacterial and antioxidant properties of Cuminum Cyminum L. essential oil. Journal of Food Industry Research, 2012. 22(3): p. 311-321.
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