Design and Optimization of a Self-Nanoemulsifying Drug Delivery System for Pranlukast Hemihydrate with D-Optimal Mixture Design D-Optimal Design based SNEDDS development for Pranlukast Hemihydrate
Iranian Journal of Pharmaceutical Sciences,
Vol. 21 No. 1 (2025),
21 Bahman 2025
,
Page 312-322
https://doi.org/10.22037/ijps.v21i1.46877
Abstract
The researchers optimized the concentrations of components in the SNEDDS formulation using a D-optimal mixture design, aiming to achieve favorable physicochemical characteristics like dissolution and droplet size. The optimized formulation of pranlukast-loaded SNEDDS, comprising 22.44 mg of Benzyl alcohol, 67.55 mg of Tween 20, and 10 mg of Span 20, resulted in a droplet size of 65.866 nm, saturated solubility of 20.56 mg/g, and drug release of 90.84%, with a desirability index value of 1. The comparison of among experimental and predicted values for the droplet size, saturated solubility, and the drug release showed good agreement. Consequently, they successfully developed an SNEDDS formulation using a D-optimal mixture design, which is promising for enhancing weakly water-soluble drugs' oral absorption.
- SNEDDS
- PLH
- D-optimal mixture design
- Desirability
- Droplet size
How to Cite
References
Date, Abhijit A., et al. "Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances." Nanomedicine 5.10 (2010): 1595-1616.
Bhalani, D. V., et al. "Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines 2022, 10, 2055." (2022).
Huang, Yanping, et al. "In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives." ActaPharmaceuticaSinica B 11.8 (2021): 2469-2487.
Hsieh, Chien-Ming, et al. "Application of design of experiments in the development of self-microemulsifying drug delivery systems." Pharmaceuticals 16.2 (2023): 283.
Zhu, Yujin, Jing Ye, and Quan Zhang. "Self-emulsifying drug delivery system improve oral bioavailability: role of excipients and physico-chemical characterization." Pharmaceutical Nanotechnology 8.4 (2020): 290-301..
Renugopal, P., S. Sangeetha, and N. Damodharan. "An Emerging Trend in Solid Self Micro Emulsifying Drug Delivery System." Research Journal of Pharmacy and Technology 13.6 (2020): 3028-3034.
Salawi, Ahmad. "Self-emulsifying drug delivery systems: a novel approach to deliver drugs." Drug Delivery 29.1 (2022): 1811-1823.
Khadka, Prakash, et al. "Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability." Asian journal of pharmaceutical sciences 9.6 (2014): 304-316.
Ankenman, Bruce E., and Angela M. Dean. "Ch. 8. Quality improvement and robustness via design of experiments." Handbook of statistics 22 (2003): 263-317.
Beg, Sarwar, et al. "Application of design of experiments (DoE) in pharmaceutical product and process optimization." Pharmaceutical quality by design. Academic Press, 2019. 43-64.
Uchiyama, Hiromasa, et al. "A simple blending with α-glycosylated naringin produces enhanced solubility and absorption of pranlukast hemihydrate." International Journal of Pharmaceutics 567 (2019): 118490.
Serajuddin, Abu TM. "Salt formation to improve drug solubility." Advanced drug delivery reviews 59.7 (2007): 603-616.
Gershanik, Tatyana, and Simon Benita. "Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs." European journal of pharmaceutics and biopharmaceutics 50.1 (2000): 179-188.
Jain, Sourabhkumar, et al. "DoE-based solid self-microemulsifying drug delivery system (S-smedds) approach for improving the dissolution properties of Raltegravir potassium." Journal of Pharmaceutical Innovation 18.1 (2023): 29-42.
Eleftheriadis, Georgios K., et al. "Development and characterization of a self-nanoemulsifying drug delivery system comprised of rice bran oil for poorly soluble drugs." AapsPharmscitech 20 (2019): 1-14.
Luiz, Marcela Tavares, et al. "Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems." European Journal of Pharmaceutics and Biopharmaceutics 165 (2021): 127-148.
Lee, Jong-Hwa, and Gye-Won Lee. "Formulation approaches for improving the dissolution behavior and bioavailability of Tolvaptan using SMEDDS." Pharmaceutics 14.2 (2022): 415.
Goo, Yoon Tae, et al. "Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design." Drug delivery 29.1 (2022): 2831-2845.
Teaima, Mahmoud, et al. "Design and optimization of pioglitazone hydrochloride self-nanoemulsifying drug delivery system (SNEDDS) incorporated into an orally disintegrating tablet." Pharmaceutics 14.2 (2022): 425.
Sisinthy, SreenivasPatro, NalamoluKoteswara Rao, and Chin Yi Lynn Sarah. "Design, optimization and in vitro characterization of self nano emulsifying drug delivery system of olmesartanmedoxomil." Int J Pharm PharmSci 9.1 (2017): 94-101.
Mahore, Jayashri, et al. "Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design." J. Res. Pharm 25 (2021): 179-195.
Derringer, George, and Ronald Suich. "Simultaneous optimization of several response variables." Journal of quality technology 12.4 (1980): 214-219.
Wiącek, Agnieszka, and Emil Chibowski. "Zeta potential, effective diameter and multimodal size distribution in oil/water emulsion." Colloids and Surfaces A: Physicochemical and Engineering Aspects 159.2-3 (1999): 253-261.
- Abstract Viewed: 251 times
- IJPS_Volume21_Issue1_Pages312-322 Downloaded: 194 times